Document Detail

Hemodynamic effects of partial liquid ventilation with perfluorocarbon in acute lung injury.
MedLine Citation:
PMID:  8750120     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To assess the effect of partial liquid ventilation with perfluorocarbons on hemodynamics and gas exchange in large pigs with induced acute lung injury (ALI). DESIGN: Randomized, prospective, double-control, experimental study. Experimental intensive care unit of a university. MATERIALS: Eighteen large pigs (50 +/- 5 kg body weight) with an average anterior posterior thoracic diameter of 24 cm and induced acute lung injury. INTERVENTIONS: All animals were surfactant depleted by lung lavage to a PaO2 below 100 mmHg and randomized to receive either perflubron (n = 6) or saline (n = 6) in five intratracheal doses of 5 ml/kg at 20-min intervals, or no instillation (n = 6). MEASUREMENTS AND RESULTS: In all animals heart rate, arterial pressures, pulmonary pressures, cardiac output and blood gases were recorded at 20-min intervals. There was no deleterious effect on any hemodynamic parameter in the perflubron group, whereas systolic and mean pulmonary arterial pressure values showed a persistent decrease after the first 5 ml/kg of perflubron, from 48.7 +/- 14.1 to 40.8 +/- 11.7 mmHg and from 39.7 +/- 13.2 to 35.2 +/- 12.0 mmHg, respectively. Perflubron resulted in a significant (ANOVA P < 0.01), dose-dependent increase in PaO2 values from 86.3 +/- 22.4 to a maximum of 342.4 +/- 59.4 mmHg at a dose of 25 ml/kg; the other groups showed no significant increase in PaO2. CONCLUSIONS: Tracheal instillation of perflubron in induced ALI results in a dose-dependent increase in PaO2 and has no deleterious effect on hemodynamic parameters.
R J Houmes; S J Verbrugge; E R Hendrik; B Lachmann
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Intensive care medicine     Volume:  21     ISSN:  0342-4642     ISO Abbreviation:  Intensive Care Med     Publication Date:  1995 Dec 
Date Detail:
Created Date:  1996-10-21     Completed Date:  1996-10-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7704851     Medline TA:  Intensive Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  966-72     Citation Subset:  IM    
Department of Anesthesiology, Erasmus University, Rotterdam, The Netherlands.
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MeSH Terms
Acid-Base Equilibrium
Analysis of Variance
Dose-Response Relationship, Drug
Double-Blind Method
Emulsions / therapeutic use*
Fluorocarbons / therapeutic use*
Prospective Studies
Pulmonary Gas Exchange
Respiration, Artificial / methods*
Respiratory Distress Syndrome, Adult / physiopathology,  therapy*
Respiratory Function Tests
Supine Position
Reg. No./Substance:
0/Emulsions; 0/Fluorocarbons; 423-55-2/perflubron
Comment In:
Intensive Care Med. 1995 Dec;21(12):963-5   [PMID:  8750119 ]

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