Document Detail

Hemodynamic effects of morphine during and early after cardiac operations.
MedLine Citation:
PMID:  942829     Owner:  NLM     Status:  MEDLINE    
Hemodynamics and blood gases were measured before and 15 minutes after small (10 mg/70 kg) doses of intravenously administered morphine in two groups of patients having open heart surgery. In one group, the study was undertaken after median sternotomy but before perfusion. The other group had been in the intensive care unit for approximately 1 hour. No changes were found in either group in cardiac index, atrial pressures, arterial pressure, or blood gas variables. However, mean systemic vascular resistance decreased from 41.5 to 35.4 after morphine was given postoperatively. Hence, hemodynamically, morphine is a safe drug if given in small doses for pain relief and sedation early after open heart surgery.
E A Moffitt; S Tarhan; R Rodriguez; D A Barnhorst; J R Pluth
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Anesthesia and analgesia     Volume:  55     ISSN:  0003-2999     ISO Abbreviation:  Anesth. Analg.     Publication Date:    1976 Jan-Feb
Date Detail:
Created Date:  1976-03-30     Completed Date:  1976-03-30     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  1310650     Medline TA:  Anesth Analg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  47-50     Citation Subset:  IM    
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MeSH Terms
Anesthesia, Intravenous
Blood Gas Analysis
Cardiac Surgical Procedures*
Heart / drug effects
Heart Rate / drug effects
Hemodynamics / drug effects*
Middle Aged
Morphine / pharmacology*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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