Document Detail

Hemodynamic effects of lidocaine in the thoracic paravertebral space during one-lung ventilation for thoracic surgery.
MedLine Citation:
PMID:  17023281     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: There is increasing interest in the use of the thoracic paravertebral block (TPVB) in association with general anesthesia for lung-resection surgery. The aim of the study was to evaluate the hemodynamic effects of a 5-mg/kg lidocaine bolus injected in the thoracic paravertebral space during one-lung ventilation (OLV) in noncardiac patients undergoing thoracic surgery.
DESIGN: Prospective, observational study.
SETTING: Tertiary care university hospital.
PARTICIPANT: Twenty patients undergoing thoracotomy for lung resection.
INTERVENTIONS: In addition to standard monitoring, cardiac output, preload parameters (global diastolic volume, total intrathoracic blood volume, and systolic volume variation), and myocardial contractility (dP(max) and cardiac function index) were measured with an aortic transpulmonary thermodilution technique.
MEASUREMENTS AND MAIN RESULTS: After OLV initiation, a paravertebral lidocaine bolus of 5 mg/kg (2%) caused decreases in the dP(max) and cardiac function index that lasted up to 30 minutes. Accompanying minor reductions in heart rate and systolic blood pressure required no vasoactive drugs and were self-limiting. None of the other hemodynamic parameters studied was significantly altered.
CONCLUSIONS: In noncardiac patients, TPVB is associated with good hemodynamic stability, despite a small and transient decrease in myocardial contractility that could be related to the drug's systemic effects after its absorption.
Ignacio Garutti; Luis Olmedilla; Jose María Pérez-Peña; Daniel Arnal; Patricia Piñeiro; Santos Barrigon; Juan Navia
Publication Detail:
Type:  Journal Article     Date:  2006-06-05
Journal Detail:
Title:  Journal of cardiothoracic and vascular anesthesia     Volume:  20     ISSN:  1053-0770     ISO Abbreviation:  J. Cardiothorac. Vasc. Anesth.     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-10-06     Completed Date:  2007-01-16     Revised Date:  2014-07-29    
Medline Journal Info:
Nlm Unique ID:  9110208     Medline TA:  J Cardiothorac Vasc Anesth     Country:  United States    
Other Details:
Languages:  eng     Pagination:  648-51     Citation Subset:  IM    
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MeSH Terms
Anesthesia, Local / methods*
Anesthetics, Local / administration & dosage*
Blood Pressure / drug effects*,  physiology
Cardiac Output / drug effects*,  physiology
Follow-Up Studies
Lidocaine / administration & dosage*
Pneumonectomy / methods
Prospective Studies
Respiration, Artificial / methods*
Thoracic Vertebrae
Thoracotomy / methods*
Treatment Outcome
Reg. No./Substance:
0/Anesthetics, Local; 98PI200987/Lidocaine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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