Document Detail


Hemodynamic effects of levcromakalim in neonatal porcine pulmonary hypertension.
MedLine Citation:
PMID:  11474154     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Levcromakalim (LKM; a K(ATP) channel opener) reverses hypoxic pulmonary vasoconstriction in isolated pulmonary arteries and perfused lungs. This vasorelaxation is blocked by glibenclamide (GLB; a K(ATP) channel blocker). We evaluated the hemodynamic effect of LKM followed by GLB in a chronically instrumented neonatal porcine model of pulmonary hypertension, created by exposing piglets to hypoxia (n = 7) or heat-killed group B streptococci (GBS) (n = 6). Hypoxia increased pulmonary arterial pressure (PAP), which LKM decreased, and GLB subsequently increased in a dose-dependent manner. Systemic arterial pressure (SAP) did not change with hypoxia but was also decreased by LKM and increased by GLB. GBS also led to increased PAP, but LKM significantly reduced only SAP, which was then increased by GLB. We conclude LKM is capable of reversing hypoxic, but not GBS-induced, pulmonary hypertension but lacks specificity for the neonatal pulmonary vasculature.
Authors:
N Ambalavanan; A Bulger; J Ware; J Philips
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biology of the neonate     Volume:  80     ISSN:  0006-3126     ISO Abbreviation:  Biol. Neonate     Publication Date:  2001 Jul 
Date Detail:
Created Date:  2001-07-27     Completed Date:  2001-09-27     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0247551     Medline TA:  Biol Neonate     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  74-80     Citation Subset:  IM    
Copyright Information:
Copyright 2001 S. Karger AG, Basel
Affiliation:
Department of Pediatrics, University of Alabama at Birmingham, 35233, USA. ambal@sprynet.com
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn*
Anoxia
Blood Pressure / drug effects
Cromakalim / therapeutic use*
Disease Models, Animal
Glyburide / pharmacology
Hemodynamics / drug effects*
Hypertension, Pulmonary / drug therapy*,  etiology,  physiopathology
Ion Channel Gating / drug effects
Potassium Channels / drug effects,  physiology
Streptococcus agalactiae
Swine
Vascular Resistance / drug effects
Vasodilator Agents / therapeutic use*
Chemical
Reg. No./Substance:
0/Potassium Channels; 0/Vasodilator Agents; 10238-21-8/Glyburide; 94470-67-4/Cromakalim

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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