| Hemodynamic effects of leukotriene (LT) D4 and a LTD4 receptor antagonist in the pig. | |
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MedLine Citation:
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PMID: 1963540 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Vascular bed reactivity to exogenous LTD4 and blockade of these responses by a selective LTD4 receptor antagonist, SK&F 104353, were studied. Yorkshire pigs (N = 13; 25.8 +/- 1.4 kg) were anesthetized with isoflurane, and monitored for cardiac output (CO), mean pulmonary artery pressure (MPAP), pulmonary capillary wedge pressure (PCWP), right ventricular stroke work (RVSW), mean arterial pressure (MAP), renal artery blood flow (RABF), pulmonary vasculature resistance (PVR), renal vascular resistance (RVR), and systemic vascular resistance (SVR). LTD4 (0.03, 0.1, 0.3, 1, 3 and 10.0 micrograms/kg) was given intravenously. The MPAP, MAP, and RABF were recorded at baseline and for 20 min after the injection of LTD4. SK&F 104353 was infused (3 mg/kg/h, i.v.) and the dose-response to LTD4 was repeated. LTD4 induced changes in the MPAP, PCWP, MAP, and RABF. SK&F 104353 attenuated LTD4 induced changes in the MPAP, PVR, RABF and RVSW. MPAP was increased 123 +/- 24% and 115 +/- 10%, respectively, in pigs given 3.0 and 10 micrograms/kg doses, and increased to only 36 +/- 9% at a 10 micrograms/kg dose of LTD4 in animals pretreated with SK&F 104353 (P less than 0.05). MPAP was not increased at the 3.0 micrograms/kg dose, and increased to only 36 +/- 9% at a 10 micrograms/kg dose of LTD4 in animals pretreated with SK&F 104353 (P less than 0.05). These changes were paralleled by a reduction in PVR. RABF was decreased 76 +/- 5% and 83 +/- 7%, respectively, at the 3.0 and 10 micrograms/kg dose of LTD4.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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J L Zellner; J A Cook; D H Reines; W C Wise; E F Smith; L D Kessler; P V Halushka |
Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Eicosanoids Volume: 3 ISSN: 0934-9820 ISO Abbreviation: Eicosanoids Publication Date: 1990 |
Date Detail:
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Created Date: 1991-04-18 Completed Date: 1991-04-18 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8906009 Medline TA: Eicosanoids Country: GERMANY |
Other Details:
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Languages: eng Pagination: 219-24 Citation Subset: IM |
Affiliation:
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Department of Surgery, Medical University of South Carolina, Charleston 29425. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Dicarboxylic Acids / pharmacology* Dose-Response Relationship, Drug Hemodynamics / drug effects* Isoflurane / pharmacology Kinetics Receptors, Immunologic / antagonists & inhibitors* Receptors, Leukotriene SRS-A / pharmacology* Swine |
| Grant Support | |
ID/Acronym/Agency:
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GM27673/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Dicarboxylic Acids; 0/Receptors, Immunologic; 0/Receptors, Leukotriene; 0/SRS-A; 107023-41-6/pobilukast; 26675-46-7/Isoflurane |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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