Document Detail


Hemodynamic effects of a kinin antagonist.
MedLine Citation:
PMID:  1697367     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The present study was undertaken to assess in unanesthetized rats the effect of a kinin antagonist (D-Arg-Arg-Pro-Hyp-Gly-Thi-Ser-D-Phe-Thi-Arg-trifluoroacetic acid) on blood pressure, heart rate, and splanchnic nerve activity. The antagonist infused intra-arterially (50 micrograms/min) for 10 min had no blood pressure effect in control rats. It did, however, cause a significant increase in blood pressure in animals preinfused with a nonpressor dose of angiotensin II (1 ng/min i.v.) for 70 min. The antagonist-induced blood pressure rise was not associated with an increase in splanchnic nerve activity. Acute angiotensin-converting enzyme (ACE) inhibition with captopril (2.5 mg i.v.) had no influence on the pressor response to the kinin antagonist in angiotensin II-treated rats. These results obtained in conscious normotensive rats suggest that endogenous kinins participate in the control of blood pressure by attenuating the vasoconstrictor effect of angiotensin II. The involvement of kinin does not seem to be enhanced by acute ACE inhibition.
Authors:
B Waeber; M Niederberger; H Gavras; J Nussberger; H R Brunner
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  15 Suppl 6     ISSN:  0160-2446     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:  1990  
Date Detail:
Created Date:  1990-10-04     Completed Date:  1990-10-04     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  S78-82     Citation Subset:  IM    
Affiliation:
Division of Hypertension, University Hospital, Lausanne, Switzerland.
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Angiotensin II / pharmacology
Angiotensin-Converting Enzyme Inhibitors / pharmacology
Animals
Blood Pressure / drug effects
Body Weight / drug effects
Bradykinin / analogs & derivatives*,  antagonists & inhibitors,  pharmacology
Heart Rate / drug effects
Hemodynamics / drug effects*
Kinins / antagonists & inhibitors*
Male
Molecular Sequence Data
Rats
Rats, Inbred Strains
Splanchnic Nerves / drug effects
Chemical
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 0/Kinins; 103412-42-6/B 4162; 11128-99-7/Angiotensin II; 58-82-2/Bradykinin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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