Document Detail

Hemodynamic effects of intravenous somatostatin administered in the postoperative period.
MedLine Citation:
PMID:  9295819     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate the hemodynamic effects of intravenous somatostatin administration in patients during the early postoperative period. DESIGN: Prospective, case-controlled trial. SETTING: Postanesthesia care unit. PATIENTS: Ten postoperative, noncirrhotic, American Society of Anesthesiologists physical status II patients, after resection of nonsecretory (i.e., non-neuroendocrine) tumors. No patient received any vasoactive medication perioperatively. INTERVENTIONS: Three hours after the end of surgery, normal saline or somatostatin was intravenously administered in two phases: a) in phase 1, patients received a 20-mL bolus of normal saline within 1 min, followed by a continuous infusion of 20 mL of normal saline for the next 30 mins. Patients were left undisturbed for the subsequent 30 mins. b) in phase 2, patients received somatostatin (3.5 micrograms/kg, 20-mL bolus) over 1 min, followed by a continuous infusion of somatostatin (3.5 micrograms/kg/hr) for 72 hrs. MEASUREMENTS AND MAIN RESULTS: Anesthesia was managed according to a prospectively designed protocol. Patients' hemodynamic profiles and pressure waveforms were recorded immediately before the bolus injections of normal saline and somatostatin, and at every minute thereafter for 30 mins. Bolus doses of somatostatin produced a transient, nonsignificant decrease in heart rate, along with short-lived increases in systolic arterial pressure, diastolic arterial pressure, systolic pulmonary arterial pressure, diastolic pulmonary arterial pressure, and central venous pressure. CONCLUSION: Bolus intravenous somatostatin administered postoperatively after tumor resection in patients produced transient cardiovascular changes that were not sustained during a subsequent continuous infusion.
A Petru; D Michaloudis; F Kanakoudis; H Askitopoulou; D B Carr
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Critical care medicine     Volume:  25     ISSN:  0090-3493     ISO Abbreviation:  Crit. Care Med.     Publication Date:  1997 Sep 
Date Detail:
Created Date:  1997-10-02     Completed Date:  1997-10-02     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0355501     Medline TA:  Crit Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1468-71     Citation Subset:  AIM; IM    
Anesthesiology Department, Theagenio Anticancer Hospital, Thessaloniki, Greece.
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MeSH Terms
Chemotherapy, Adjuvant
Drug Monitoring
Hemodynamics / drug effects*
Hormone Antagonists / therapeutic use*
Infusions, Intravenous
Injections, Intravenous
Middle Aged
Neoplasms / surgery*
Postoperative Period
Prospective Studies
Somatostatin / therapeutic use*
Time Factors
Reg. No./Substance:
0/Hormone Antagonists; 51110-01-1/Somatostatin

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