| Hemodynamic effects of intravenous flecainide in acute noncomplicated myocardial infarction. | |
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MedLine Citation:
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PMID: 4072876 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hemodynamic and ECG effects of intravenous flecainide were assessed in 10 patients with acute myocardial infarction and no symptoms or signs of heart failure. The dose was 2 mg/kg injected over a 15-minute period. R-R interval did not change, but PR interval and QRS increased significantly, 28% (p less than 0.0005) and 20% (p less than 0.05), respectively. Duration of P wave also increased significantly, 15% (p less than 0.02). Pulmonary wedge pressure increased 29% (p less than 0.005) and cardiac index and left ventricular stroke work index decreased 9% (p less than 0.05) and 20% (p less than 0.05), respectively. No significant change in mean aortic pressure and systemic vascular resistance occurred. Thus, intravenous flecainide has a mild and transient negative inotropic effect in patients with noncomplicated acute myocardial infarction. It did not induce ventricular failure in this group of patients but should be administered cautiously to patients with overt heart failure or severe conduction defects. |
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Authors:
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A A Cohen; V Daru; G Covelli; M Gonzalez; R Villamayor; J E Tronge |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American heart journal Volume: 110 ISSN: 0002-8703 ISO Abbreviation: Am. Heart J. Publication Date: 1985 Dec |
Date Detail:
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Created Date: 1985-12-31 Completed Date: 1985-12-31 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370465 Medline TA: Am Heart J Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1193-6 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Electrocardiography Female Flecainide Heart Conduction System / drug effects Hemodynamics / drug effects* Humans Male Middle Aged Myocardial Contraction / drug effects Myocardial Infarction / drug therapy*, physiopathology Piperidines / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Piperidines; 54143-55-4/Flecainide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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