Document Detail

Hemodynamic effects of intravenous flecainide in acute noncomplicated myocardial infarction.
MedLine Citation:
PMID:  4072876     Owner:  NLM     Status:  MEDLINE    
Hemodynamic and ECG effects of intravenous flecainide were assessed in 10 patients with acute myocardial infarction and no symptoms or signs of heart failure. The dose was 2 mg/kg injected over a 15-minute period. R-R interval did not change, but PR interval and QRS increased significantly, 28% (p less than 0.0005) and 20% (p less than 0.05), respectively. Duration of P wave also increased significantly, 15% (p less than 0.02). Pulmonary wedge pressure increased 29% (p less than 0.005) and cardiac index and left ventricular stroke work index decreased 9% (p less than 0.05) and 20% (p less than 0.05), respectively. No significant change in mean aortic pressure and systemic vascular resistance occurred. Thus, intravenous flecainide has a mild and transient negative inotropic effect in patients with noncomplicated acute myocardial infarction. It did not induce ventricular failure in this group of patients but should be administered cautiously to patients with overt heart failure or severe conduction defects.
A A Cohen; V Daru; G Covelli; M Gonzalez; R Villamayor; J E Tronge
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American heart journal     Volume:  110     ISSN:  0002-8703     ISO Abbreviation:  Am. Heart J.     Publication Date:  1985 Dec 
Date Detail:
Created Date:  1985-12-31     Completed Date:  1985-12-31     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1193-6     Citation Subset:  AIM; IM    
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MeSH Terms
Heart Conduction System / drug effects
Hemodynamics / drug effects*
Middle Aged
Myocardial Contraction / drug effects
Myocardial Infarction / drug therapy*,  physiopathology
Piperidines / therapeutic use*
Reg. No./Substance:
0/Piperidines; 54143-55-4/Flecainide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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