| Hemodynamic effects of intravenous diltiazem in patients with recent myocardial infarction. | |
| | |
MedLine Citation:
|
PMID: 7066936 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The hemodynamic effects of intravenous diltiazem, 0.2 mg/kg, were examined in eight patients with recent myocardial infarction. Diltiazem lowered mean aortic pressure (87.0 +/- 3.3 to 79.9 +/- 3.1 mmHg, P less than 0.01) and systemic vascular resistance (1353.0 +/- 136.2 to 964.9 +/- 101.7 dynes.sec.cm-5, P less than 0.01), and increased cardiac index (3.77 +/- 0.27 to 4.72 +/- 0.41 liters/min/sq m, P less than 0.01) and stroke index (57.5 +/- 4.5 to 69.4 +/- 7.6 ml/beat/sq m, P less than 0.05). No significant changes in the left ventricular end-diastolic, right atrial, and pulmonary arterial pressure, or heart rate were noted after diltiazem. These results suggest that the negative inotropic effects of diltiazem are negligible even in patients with recent myocardial infarction. The electrocardiogram should be observed carefully, however, since the PR interval was further prolonged in one patient who had first-degree atrioventricular block before diltiazem. |
| | |
Authors:
|
Y Koiwaya; A Takeshita; M Nakamura |
Related Documents
:
|
831426 - Angiographic findings in asymptomatic aircrewmen with electrocardiographic abnormalities. 2730126 - Follow up study of cardiac involvement in emery-dreifuss muscular dystrophy. 16580416 - Right ventricular enlargement mimicking electrocardiographic left ventricular pacing. 3511096 - Distribution of cardiac myosin isozymes in human conduction system. immunohistochemical... 8049586 - Compensatory and maladaptive responses to cardiac dysfunction. 10468256 - Anesthetic management of patients undergoing coronary artery bypass grafting with the u... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Clinical therapeutics Volume: 4 ISSN: 0149-2918 ISO Abbreviation: Clin Ther Publication Date: 1982 |
Date Detail:
|
Created Date: 1982-06-21 Completed Date: 1982-06-21 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 7706726 Medline TA: Clin Ther Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 381-9 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Benzazepines / therapeutic use* Cardiac Output / drug effects Diltiazem / therapeutic use* Electrocardiography Female Heart Catheterization Heart Rate / drug effects Hemodynamics / drug effects* Humans Injections, Intravenous Male Middle Aged Myocardial Infarction / drug therapy*, physiopathology Time Factors |
| Chemical | |
Reg. No./Substance:
|
0/Benzazepines; 42399-41-7/Diltiazem |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Genetic forms of neoplasia in man: a model for the study of tumor promotion in vitro.
Next Document: Tracheal epithelium: cell kinetics and differentiation in normal rat tissue.