Document Detail

Hemodynamic effects of intravenous amiodarone.
MedLine Citation:
PMID:  6470338     Owner:  NLM     Status:  MEDLINE    
Amiodarone is a potent antiarrhythmic agent that is effective in controlling both atrial and ventricular arrhythmias. Recently, intravenous administration was demonstrated to be effective in the acute management of rhythm disorders and, in addition, appeared to shorten the loading period normally required for oral drug administration. This investigation examined the hemodynamic effects of amiodarone after both acute intravenous bolus and continuous intravenous administration. Patients with a left ventricular ejection fraction greater than 0.35 experienced improved cardiac performance due to both acute and chronic peripheral vasodilation. However, patients with a lower ejection fraction developed a 20% decrease in cardiac index and clinically significant elevation of right heart pressures after acute bolus administration; these changes were variably compensated for by peripheral vasodilation when the drug was administered intravenously over 3 to 5 days continuously. Therefore, intravenous amiodarone can result in significant impairment of left ventricular performance in patients with preexisting left ventricular dysfunction.
E J Kosinski; J B Albin; E Young; S M Lewis; O S LeLand
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the American College of Cardiology     Volume:  4     ISSN:  0735-1097     ISO Abbreviation:  J. Am. Coll. Cardiol.     Publication Date:  1984 Sep 
Date Detail:
Created Date:  1984-09-26     Completed Date:  1984-09-26     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8301365     Medline TA:  J Am Coll Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  565-70     Citation Subset:  IM    
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MeSH Terms
Amiodarone / administration & dosage,  adverse effects,  pharmacology*
Arrhythmias, Cardiac / drug therapy*,  physiopathology
Benzofurans / pharmacology*
Blood Pressure / drug effects
Cardiac Output / drug effects
Hemodynamics / drug effects*
Injections, Intravenous
Pulmonary Artery / physiopathology
Vascular Resistance / drug effects
Reg. No./Substance:
0/Benzofurans; 1951-25-3/Amiodarone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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