Document Detail

Hemodynamic effects of high doses of corticosteroids.
MedLine Citation:
PMID:  2868597     Owner:  NLM     Status:  MEDLINE    
It is somewhat difficult to reconcile the contrasting findings regarding the hemodynamic actions of high doses of corticosteroids in shock. The studies differ according to type of shock (hypovolemic, septic or cardiogenic), animal species, shock model, type of corticosteroid, etc. Beneficial hemodynamic effects (e.g. myocardial improvement, vasodilation) of steroids given alone are not consistently observed and when so often mild and transient. This might indicate that the hemodynamic changes of corticosteroids are not due to primary actions on the cardiovascular system but rather represent the hemodynamic consequences of the metabolic response to corticosteroid therapy. If, however, the corticosteroid therapy is combined with an alpha-adrenoreceptor blocker the nutritive tissue blood flow is distinctly increased.
A Hellman; D Lundberg
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta chirurgica Scandinavica. Supplementum     Volume:  526     ISSN:  0301-1860     ISO Abbreviation:  Acta Chir Scand Suppl     Publication Date:  1985  
Date Detail:
Created Date:  1986-03-12     Completed Date:  1986-03-12     Revised Date:  2007-12-06    
Medline Journal Info:
Nlm Unique ID:  0370305     Medline TA:  Acta Chir Scand Suppl     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  13-8     Citation Subset:  IM    
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MeSH Terms
Adrenal Cortex Hormones / pharmacology*,  therapeutic use
Bretylium Compounds / pharmacology
Cardiac Output / drug effects
Hemodynamics / drug effects*
Hexamethonium Compounds / pharmacology
Hydrocortisone / pharmacology
Methylprednisolone / pharmacology
Norepinephrine / physiology
Phenoxybenzamine / pharmacology
Propranolol / pharmacology
Shock, Hemorrhagic / drug therapy*
Vasodilation / drug effects
Reg. No./Substance:
0/Adrenal Cortex Hormones; 0/Bretylium Compounds; 0/Hexamethonium Compounds; 50-23-7/Hydrocortisone; 51-41-2/Norepinephrine; 525-66-6/Propranolol; 59-41-6/bretylium; 59-96-1/Phenoxybenzamine; 60-26-4/Hexamethonium; 83-43-2/Methylprednisolone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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