| Hemodynamic effects of glomerular permselectivity. | |
| | |
MedLine Citation:
|
PMID: 2256473 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Glomerular capillary hemodynamics influence glomerular permselectivity to macromolecules, and alterations in these factors can evoke proteinuria. Changes in hemodynamic patterns can alter protein flux by changing its diffusion- or concentration-driven movement in the presence of a constant membrane barrier. Alternatively, hemodynamic forces may disrupt, transiently or irreversibly, the permeability characteristics of the capillary barrier. Maneuvers that lower glomerular capillary pressure appear capable of reversing at least in part, these latter permeability defects. Angiotensin II, provoked by higher levels of dietary protein intake, may be a particularly important mediator of proteinuria both through its effects on diffusion-mediated protein leakage and its tendency to provoke permeability defects due to heightening of glomerular capillary hydraulic pressures. |
| | |
Authors:
|
T H Hostetter; M E Rosenberg |
Related Documents
:
|
19692493 - Hydrolyzed dietary casein as compared with the intact protein reduces postprandial peri... 8322773 - Low-protein diets and angiotensin-converting enzyme inhibition in progressive renal fai... 6848503 - Fluorescence of histones h1. a tyrosinate-like fluorescence emission in ceratitis capit... |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: American journal of nephrology Volume: 10 Suppl 1 ISSN: 0250-8095 ISO Abbreviation: Am. J. Nephrol. Publication Date: 1990 |
Date Detail:
|
Created Date: 1991-01-24 Completed Date: 1991-01-24 Revised Date: 2007-02-14 |
Medline Journal Info:
|
Nlm Unique ID: 8109361 Medline TA: Am J Nephrol Country: SWITZERLAND |
Other Details:
|
Languages: eng Pagination: 24-7 Citation Subset: IM |
Affiliation:
|
University of Minnesota, Minneapolis. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Angiotensin II
/
physiology Capillary Permeability / physiology Dietary Proteins / pharmacology Glomerular Filtration Rate / physiology Humans Kidney Glomerulus / physiology* Microcirculation / physiology Proteinuria / etiology* |
| Chemical | |
Reg. No./Substance:
|
0/Dietary Proteins; 11128-99-7/Angiotensin II |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Glomerular polyanion and control of cell function.
Next Document: Metabolism of albumin and immunoglobulins in the nephrotic syndrome.