Document Detail

Hemodynamic effects of fructose 1,6-diphosphate in patients with normal and impaired left ventricular function.
MedLine Citation:
PMID:  9141376     Owner:  NLM     Status:  MEDLINE    
We compared the short-term hemodynamic effects of intravenous fructose 1,6-diphosphate (FDP) administration in patients with coronary artery disease. Hemodynamic measurements were performed before and after administration of FDP in two groups of patients: those with impaired left ventricular (LV) function, elevated LV end-diastolic pressures (LVEDP > or =12 mm Hg, n = 30), and those with normal LV function (LVEDP <12 mm Hg, n = 17). In those with impaired LV function, FDP induced a decrease in LVEDP from 22 +/- 1.31 to 16.73 +/- 1.46 mm Hg (p< 0.0001). The cardiac index increased (2.50 +/- 0.11 to 2.81 +/- 0.13 L/m2 [p < 0.0001]), as did the LV stroke work index (31.7 +/- 2.04 to 40.3 +/- 2.67 gm x m x m2 [p < 0.0001]). FDP induced no significant change in heart rate and mean aortic pressure. Pulmonary pressure and resistance declined (p<0.002 and p< 0.0001, respectively). Systemic vascular resistance decreased because of increased cardiac output and unchanged arterial pressure (p < 0.001). In those patients with normal baseline LVEDP (5.06 +/- 0.27 mm Hg), FDP decreased heart rate (p< 0.0001) and systemic and pulmonary resistance (p < 0.03 and p < 0.004, respectively), whereas LVEDP and mean aortic and pulmonary pressures remained unchanged. FDP moderately increased cardiac output (p < 0.05), stroke volume index, and LV stroke work index (p< 0.002 and p< 0.003, respectively). The observed improvement in LV function in those patients with elevated LV filling pressures is thought to be a result of an increased energy production by the Embden-Meyerhoff pathway and to act as a positive inotrope.
A K Markov; M A Brumley; A Figueroa; T N Skelton; P H Lehan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American heart journal     Volume:  133     ISSN:  0002-8703     ISO Abbreviation:  Am. Heart J.     Publication Date:  1997 May 
Date Detail:
Created Date:  1997-05-23     Completed Date:  1997-05-23     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  541-9     Citation Subset:  AIM; IM    
Department of Medicine, The University of Mississippi Medical Center, Jackson 39216, USA.
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MeSH Terms
Case-Control Studies
Coronary Disease / physiopathology*
Energy Metabolism / drug effects
Fructosediphosphates / administration & dosage,  pharmacology*
Heart Catheterization
Hemodynamics / drug effects*
Infusions, Intravenous
Middle Aged
Myocardium / metabolism
Time Factors
Ventricular Dysfunction, Left / physiopathology*
Ventricular Function, Left / drug effects*
Reg. No./Substance:
0/Fructosediphosphates; 488-69-7/fructose-1,6-diphosphate

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