| Hemodynamic effects of exogenous nitric oxide in ovine transitional pulmonary circulation. | |
| | |
MedLine Citation:
|
PMID: 1415614 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
To determine the hemodynamic effects of exogenous nitric oxide (NO) on the immature pulmonary circulation, we studied the response to NO inhalation in 19 mechanically ventilated late-gestation ovine fetuses in three separate protocols. In protocol 1, we examined the relative effects of 1) mechanical ventilation while maintaining fetal arterial O2 tension (PaO2) constant [fractional inspired O2 concentration (FIO2) less than 0.10)], 2) NO inhalation [5-20 parts per million (ppm)] at fetal PaO2, and 3) high FIO2 (1.00) (n = 7). NO increased left pulmonary artery blood flow (Qlpa) in a dose-dependent fashion, from 254 +/- 62 (baseline) to 398 +/- 49 ml/min with 20 ppm NO (P less than 0.001). The response of Qlpa to a FIO2 equal to 1.00 was not different from NO alone. Systemic arterial pressure was not affected by NO. In protocol 2 we studied the effects of prolonged NO inhalation (2 h, 20 ppm) during mechanical ventilation with low FIO2 (n = 4). NO increased Qlpa from 267 +/- 92 to 468 +/- 75 ml/min at 10 min of NO inhalation (P less than 0.001). The increase in Qlpa was sustained during the entire 2-h study period. In protocol 3 we measured left ventricular output (LVO), systemic vascular resistance (SVR), and ductus arteriosus shunting using radiolabeled microspheres (n = 8) during baseline mechanical ventilation and 20 ppm NO inhalation. LVO and SVR were not significantly different in the two study periods; however, the percentage of LVO that reached the lungs (predominantly left-to-right shunting across the ductus arteriosus) increased from 18 +/- 5 to 43 +/- 4% during NO inhalation.(ABSTRACT TRUNCATED AT 250 WORDS) |
| | |
Authors:
|
J P Kinsella; J A McQueston; A A Rosenberg; S H Abman |
Related Documents
:
|
17687484 - Experimental and theoretical studies of the reaction of the oh radical with alkyl sulfi... 16220074 - Differentiation of l- and d-s-nitrosothiol recognition sites in vivo. 21107584 - Daytime baroreflex sensitivity in patients with primary insomnia. 9671374 - Effects of inhaled nitric oxide during permissive hypercapnia in acute respiratory fail... 7944074 - Effect of natural oxygen enrichment at low altitude on oxygen-dependent patients with e... 15550314 - Compliance of abdominal aortic aneurysms: evaluation of tissue doppler imaging. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: The American journal of physiology Volume: 263 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1992 Sep |
Date Detail:
|
Created Date: 1992-10-29 Completed Date: 1992-10-29 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: H875-80 Citation Subset: IM |
Affiliation:
|
Department of Pediatrics, Children's Hospital, Denver, Colorado. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Administration, Inhalation Animals Dose-Response Relationship, Drug Fetus / drug effects*, physiology Hemodynamics / drug effects* Nitric Oxide / pharmacology* Pulmonary Circulation / drug effects* Respiration, Artificial Sheep Vascular Resistance / drug effects Ventricular Function, Left / drug effects |
| Grant Support | |
ID/Acronym/Agency:
|
HL-01932/HL/NHLBI NIH HHS; HL-41012/HL/NHLBI NIH HHS; HL-46481/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
10102-43-9/Nitric Oxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Na+ efflux mechanisms in ventricular myocytes: measurement of [Na+]i with Na(+)-binding benzofuran i...
Next Document: Pulmonary and systemic vascular smooth muscle mechanical characteristics in newborn sheep.