Document Detail


Hemodynamic effects of exogenous adrenomedullin in healthy and endotoxemic sheep.
MedLine Citation:
PMID:  12147239     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Adrenomedullin (AM) is a vasodilatory peptide hormone, playing a key role in the regulation of cardiovascular homeostasis. In view of the circulatory failure in sepsis, it is still debated as to whether the occurrence of vascular hyporeactivity against AM plays a causative or protective role. This study was designed as a prospective, controlled trial to elucidate the hemodynamic response following a titrating infusion of human AM in healthy and endotoxemic sheep. ANOVA demonstrated that AM infusion produced hypotension and tachycardia, and increased cardiac index in a dose-dependent manner, both in healthy and endotoxemic sheep. In addition, AM application reduced pulmonary vascular resistance index in ovine endotoxemia (P=0.02). These findings confirm that AM produces a hyperdynamic circulation, in the presence and absence of systemic inflammation. Further, exogenous AM could possibly be a useful adjunct in the common setting of sepsis-associated pulmonary hypertension.
Authors:
Martin Westphal; Henning Stubbe; Hans Georg Bone; Fritz Daudel; Sebastian Vocke; Hugo Van Aken; Michael Booke
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  296     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  2002 Aug 
Date Detail:
Created Date:  2002-07-30     Completed Date:  2002-09-06     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  United States    
Other Details:
Languages:  eng     Pagination:  134-8     Citation Subset:  IM    
Affiliation:
Department of Anaesthesiology and Intensive Care, University of Münster, Albert-Schweitzer-Strasse 33, 48149, Münster, Germany. mwestpha@uni-muenster.de
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MeSH Terms
Descriptor/Qualifier:
Adrenomedullin
Animals
Endotoxemia / physiopathology*
Hemodynamics / drug effects*
Infusions, Intravenous
Peptides / administration & dosage,  pharmacology*
Prospective Studies
Sheep
Chemical
Reg. No./Substance:
0/Peptides; 148498-78-6/Adrenomedullin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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