Document Detail


Hemodynamic effects of exchange transfusions with liposome-encapsulated hemoglobin.
MedLine Citation:
PMID:  3140919     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The ability of liposome-encapsulated hemoglobin (LEH) to sustain life in rats at hematocrits 45% below lethal levels was demonstrated by virtually total exchange transfusions. All control animals (transfused with 7% albumin in Erilyte) died at a mean hematocrit of 5.35%, with corresponding oxygen-carrying capacity of 2.65 ml/100 ml. All LEH animals survived with a final RBC hematocrit of 2.96% and an oxygen-carrying capacity of 7.05 ml/100 ml. LEH animals maintained normal blood pressures and essentially normal cardiac output, while control animals failed to do so. Systemic vascular resistance of control animals at 78% exchange was reduced to 33% of baseline, while of LEH animals at 92% exchange, to 80% of baseline. In-vitro measurements were made of LEH and RBC suspension viscosity as a function of shear rate, suspension concentration, and lipid membrane composition. The viscous behavior of the LEH suspensions was non-Newtonian and nearly the same as suspensions of natural RBC prepared similarly, though LEH suspensions had slightly higher viscosity.
Authors:
I F Miller; J Mayoral; L Djordjevich; A Kashani
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Biomaterials, artificial cells, and artificial organs     Volume:  16     ISSN:  0890-5533     ISO Abbreviation:  Biomater Artif Cells Artif Organs     Publication Date:  1988  
Date Detail:
Created Date:  1988-12-08     Completed Date:  1988-12-08     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8802605     Medline TA:  Biomater Artif Cells Artif Organs     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  281-8     Citation Subset:  IM    
Affiliation:
University of Illinois, Chicago.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure
Blood Substitutes / therapeutic use*
Blood Viscosity
Carbon Dioxide / blood
Cardiac Output
Erythrocytes / physiology
Exchange Transfusion, Whole Blood*
Female
Hematocrit
Hemodynamics*
Hemoglobins / physiology*
Humans
Hydrogen-Ion Concentration
Liposomes*
Oxygen / blood
Rats
Rats, Inbred Strains
Vascular Resistance
Chemical
Reg. No./Substance:
0/Blood Substitutes; 0/Hemoglobins; 0/Liposomes; 124-38-9/Carbon Dioxide; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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