Document Detail

Hemodynamic effects of epinephrine associated to an epidural clonidine-bupivacaïne mixture during combined lumbar epidural and general anesthesia.
MedLine Citation:
PMID:  9844703     Owner:  NLM     Status:  MEDLINE    
Clonidine or epinephrine are frequently combined to epidural local anesthetics to strengthen sensory block and prolong analgesia. Both drugs impair the hemodynamic profile of central neural blockade but the effects of their combination on arterial pressure and heart rate are not known and were examined in this double-blind prospective randomised study. Forty four patients scheduled for lumbar disc surgery were allocated to two groups. Epidural anesthesia was obtained by administration of 150 micrograms clonidine in 15 ml bupivacaine 0.25% solution without (group C) or with (group C + E) 37.5 micrograms epinephrine. Systolic, mean, diastolic arterial pressure and heart rate were measured throughout the study. Combined epidural and general anesthesia induced a significant decrease in arterial pressure and heart rate in both groups. SAP and MAP decreased significantly less in the patients receiving epinephrine. Low dose epidural epinephrine decreases arterial pressure instability during combined epidural and general anesthesia.
M Senard; D Ledoux; P L Darmon; P Hans; J F Brichant; F Bonnet
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Acta anaesthesiologica Belgica     Volume:  49     ISSN:  0001-5164     ISO Abbreviation:  Acta Anaesthesiol Belg     Publication Date:  1998  
Date Detail:
Created Date:  1999-02-23     Completed Date:  1999-02-23     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0421022     Medline TA:  Acta Anaesthesiol Belg     Country:  BELGIUM    
Other Details:
Languages:  eng     Pagination:  167-73     Citation Subset:  IM    
University Department of Anesthesia and Surgical Intensive Care, CHR de la Citadelle, Liege, Belgium.
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MeSH Terms
Adrenergic alpha-Agonists / administration & dosage*
Analgesia, Epidural
Analysis of Variance
Anesthesia, Epidural*
Anesthesia, General*
Anesthetics, Local / administration & dosage*
Blood Pressure / drug effects*
Bupivacaine / administration & dosage*
Chi-Square Distribution
Clonidine / administration & dosage*
Double-Blind Method
Epinephrine / administration & dosage*
Heart Rate / drug effects*
Intervertebral Disk / surgery
Lumbar Vertebrae / surgery
Middle Aged
Nerve Block
Prospective Studies
Reg. No./Substance:
0/Adrenergic alpha-Agonists; 0/Anesthetics, Local; 2180-92-9/Bupivacaine; 4205-90-7/Clonidine; 51-43-4/Epinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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