Document Detail

Hemodynamic effects of endobronchial application of ornipressin versus terlipressin.
MedLine Citation:
PMID:  15316215     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Ornipressin and terlipressin, two ADH-derivates, are instilled endobronchially for bronchoscopy- related bleeding without sufficient evidence of efficacy, nor safety. OBJECTIVES: To compare the immediate hemodynamic effects of ornipressin and terlipressin used for procedure-related bleeding during flexible bronchoscopy. METHODS: This retrospective study included patients referred for flexible bronchoscopy who needed administration of ornipressin (15 patients) or terlipressin (15 patients) for procedure-related bleeding. Endobronchial ornipressin (5 IU) or terlipressin (0.5 mg) was administered through the bronchoscope when bleeding persisted for 2 min of continuous suction, or when bleeding was considered increasing in time or major. Hemodynamic data were collected before, during and after administration of either drug. RESULTS: Biopsy-associated hemoptysis requiring medical treatment occurred in 110 (4.2%) of 2,592 bronchoscopies. After administration of ornipressin, no significant change in heart rate or blood pressure was observed. Following terlipressin instillation, heart rate increased from 93 +/- 17 to 101 +/- 22 b.p.m. (p = 0.03), and blood pressure decreased from 107 +/- 14 to 101 +/- 17 mm Hg (p = 0.04). Oxygen saturation under supplemental nasal oxygen was not different in both groups. None of the 110 patients died from bronchoscopy-related hemoptysis or needed further intervention to stop bleeding or prolonged monitoring because of hemodynamic instability. CONCLUSIONS: In contrast to ornipressin, administration of terlipressin is associated with significant changes in heart rate and blood pressure. However, these changes are of minor clinical importance, and terlipressin can be safely given for bronchoscopy-associated bleeding.
Claudia Tüller; David Tüller; Michael Tamm; Martin H Brutsche
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Respiration; international review of thoracic diseases     Volume:  71     ISSN:  0025-7931     ISO Abbreviation:  Respiration     Publication Date:    2004 Jul-Aug
Date Detail:
Created Date:  2004-08-18     Completed Date:  2004-11-19     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0137356     Medline TA:  Respiration     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  397-401     Citation Subset:  IM    
Copyright Information:
Copyright 2004 S. Karger AG, Basel
Division of Respiratory Medicine, University Hospital of Basel, Basel, Switzerland.
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MeSH Terms
Blood Pressure / drug effects*
Heart Rate / drug effects*
Hemostatics / administration & dosage,  pharmacology*
Lypressin / administration & dosage,  analogs & derivatives*,  pharmacology*
Middle Aged
Ornipressin / administration & dosage,  pharmacology*
Retrospective Studies
Reg. No./Substance:
0/Hemostatics; 14636-12-5/terlipressin; 3397-23-7/Ornipressin; 50-57-7/Lypressin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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