| Hemodynamic effects of dietary caffeine, sleep restriction, and laboratory stress. | |
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MedLine Citation:
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PMID: 15563344 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study examined the separate and interactive effects of caffeine, sleep restriction, and task-induced laboratory stress in 96 healthy male and female volunteers. Participants alternated weekly between ingesting placebo and caffeine (1.75 mg/kg) three times daily for 4 consecutive weeks, while being either rested or sleep restricted. Finapres measurements of blood pressure, cardiac output, and total peripheral resistance showed that caffeine produced persistent blood pressure increases with a vascular hemodynamic profile. Sleep restriction produced a pronounced vascular response not associated with appreciable changes in blood pressure, whereas blood pressure increases induced by cognitive activity showed mixed cardiac and vascular responses. The findings suggest that life-long dietary caffeine may contribute significantly to the development of cardiovascular disease. |
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Authors:
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Jack E James; M Elizabeth Gregg |
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Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Psychophysiology Volume: 41 ISSN: 0048-5772 ISO Abbreviation: Psychophysiology Publication Date: 2004 Nov |
Date Detail:
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Created Date: 2004-11-25 Completed Date: 2005-02-22 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0142657 Medline TA: Psychophysiology Country: United States |
Other Details:
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Languages: eng Pagination: 914-23 Citation Subset: IM |
Affiliation:
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Department of Psychology, National University of Ireland, Galway, Ireland. j.james@nuigalway.ie |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Pressure / drug effects, physiology Caffeine / pharmacokinetics, pharmacology* Central Nervous System Stimulants / pharmacokinetics, pharmacology* Diet Female Heart Rate / drug effects, physiology Hemodynamics / drug effects, physiology* Humans Male Sex Characteristics Sleep Deprivation / physiopathology* Stress, Psychological / physiopathology* |
| Chemical | |
Reg. No./Substance:
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0/Central Nervous System Stimulants; 58-08-2/Caffeine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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