Document Detail

Hemodynamic effects of dietary caffeine, sleep restriction, and laboratory stress.
MedLine Citation:
PMID:  15563344     Owner:  NLM     Status:  MEDLINE    
This study examined the separate and interactive effects of caffeine, sleep restriction, and task-induced laboratory stress in 96 healthy male and female volunteers. Participants alternated weekly between ingesting placebo and caffeine (1.75 mg/kg) three times daily for 4 consecutive weeks, while being either rested or sleep restricted. Finapres measurements of blood pressure, cardiac output, and total peripheral resistance showed that caffeine produced persistent blood pressure increases with a vascular hemodynamic profile. Sleep restriction produced a pronounced vascular response not associated with appreciable changes in blood pressure, whereas blood pressure increases induced by cognitive activity showed mixed cardiac and vascular responses. The findings suggest that life-long dietary caffeine may contribute significantly to the development of cardiovascular disease.
Jack E James; M Elizabeth Gregg
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Psychophysiology     Volume:  41     ISSN:  0048-5772     ISO Abbreviation:  Psychophysiology     Publication Date:  2004 Nov 
Date Detail:
Created Date:  2004-11-25     Completed Date:  2005-02-22     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0142657     Medline TA:  Psychophysiology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  914-23     Citation Subset:  IM    
Department of Psychology, National University of Ireland, Galway, Ireland.
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MeSH Terms
Blood Pressure / drug effects,  physiology
Caffeine / pharmacokinetics,  pharmacology*
Central Nervous System Stimulants / pharmacokinetics,  pharmacology*
Heart Rate / drug effects,  physiology
Hemodynamics / drug effects,  physiology*
Sex Characteristics
Sleep Deprivation / physiopathology*
Stress, Psychological / physiopathology*
Reg. No./Substance:
0/Central Nervous System Stimulants; 58-08-2/Caffeine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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