Document Detail

Hemodynamic effects of carvedilol infusion and the contribution of the sympathetic nervous system in rats with heart failure.
MedLine Citation:
PMID:  15539880     Owner:  NLM     Status:  MEDLINE    
We investigated the contribution of the sympathetic nervous system (SNS) in maintaining the blood pressure and in regulating the cardiac function during and after carvedilol administration in rats with heart failure (group F). Left ventricular end-diastolic pressure, percent functional shortening, and rates of intraventricular pressure rise were significantly changed by carvedilol infusion as compared with the basal values in group N (normal rats), but not in group F. The left ventricular end-diastolic pressure was elevated, corresponding to the enhancement of the plasma norepinephrine (NE) concentration caused by carvedilol infusion, in group N. The enhancement of the plasma NE concentration induced by carvedilol administration in group F was higher than that in group N. The value for the maximal hypertensive effect of NE intravenous infusion (Emax) was decreased, and the plasma NE concentration at half-maximal effect (EC50) was increased in group F as compared with the values in group N. These results indicate that the SNS (presynaptic) activity is increased and that the SNS receptor sensitivity in the cardiovascular regulation system is decreased in heart failure.
Yuichi Abe; Kenichi Watanabe; Shinji Sato; Yusuke Nagai; Fadia A Kamal; Mir I I Wahed; Juan Wen; Gurusamy Narasimman; Meilei Ma; Palaniyandi Suresh; Toshihiro Takahashi; Hitoshi Tachikawa; Takeshi Kashimura; Naohito Tanabe; Makoto Kodama; Yoshifusa Aizawa; Kenichi Yamaguchi; Makoto Miyazaki; Masao Kakemi
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pharmacology     Volume:  72     ISSN:  0031-7012     ISO Abbreviation:  Pharmacology     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2004-11-12     Completed Date:  2005-03-01     Revised Date:  2013-05-28    
Medline Journal Info:
Nlm Unique ID:  0152016     Medline TA:  Pharmacology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  213-9     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2004 S. Karger AG, Basel.
Department of Clinical Pharmacology, Niigata University of Pharmacy and Applied Life Sciences, Kamishinei-cho, Japan.
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MeSH Terms
Adrenergic alpha-Antagonists / administration & dosage,  pharmacology*
Adrenergic beta-Antagonists / administration & dosage,  pharmacology*
Blood Pressure / drug effects
Carbazoles / administration & dosage,  pharmacology*
Electrocardiography / drug effects
Heart / drug effects
Heart Failure / physiopathology*
Heart Rate / drug effects
Hemodynamics / drug effects*
Infusions, Intravenous
Myocardium / metabolism
Norepinephrine / blood
Propanolamines / administration & dosage,  pharmacology*
Rats, Inbred Lew
Sympathetic Nervous System / drug effects*
Reg. No./Substance:
0/Adrenergic alpha-Antagonists; 0/Adrenergic beta-Antagonists; 0/Carbazoles; 0/Propanolamines; 0K47UL67F2/carvedilol; 51-41-2/Norepinephrine

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