| Hemodynamic effects of carvedilol infusion and the contribution of the sympathetic nervous system in rats with heart failure. | |
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MedLine Citation:
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PMID: 15539880 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We investigated the contribution of the sympathetic nervous system (SNS) in maintaining the blood pressure and in regulating the cardiac function during and after carvedilol administration in rats with heart failure (group F). Left ventricular end-diastolic pressure, percent functional shortening, and rates of intraventricular pressure rise were significantly changed by carvedilol infusion as compared with the basal values in group N (normal rats), but not in group F. The left ventricular end-diastolic pressure was elevated, corresponding to the enhancement of the plasma norepinephrine (NE) concentration caused by carvedilol infusion, in group N. The enhancement of the plasma NE concentration induced by carvedilol administration in group F was higher than that in group N. The value for the maximal hypertensive effect of NE intravenous infusion (Emax) was decreased, and the plasma NE concentration at half-maximal effect (EC50) was increased in group F as compared with the values in group N. These results indicate that the SNS (presynaptic) activity is increased and that the SNS receptor sensitivity in the cardiovascular regulation system is decreased in heart failure. |
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Authors:
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Yuichi Abe; Kenichi Watanabe; Shinji Sato; Yusuke Nagai; Fadia A Kamal; Mir I I Wahed; Juan Wen; Gurusamy Narasimman; Meilei Ma; Palaniyandi Suresh; Toshihiro Takahashi; Hitoshi Tachikawa; Takeshi Kashimura; Naohito Tanabe; Makoto Kodama; Yoshifusa Aizawa; Kenichi Yamaguchi; Makoto Miyazaki; Masao Kakemi |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Pharmacology Volume: 72 ISSN: 0031-7012 ISO Abbreviation: Pharmacology Publication Date: 2004 Dec |
Date Detail:
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Created Date: 2004-11-12 Completed Date: 2005-03-01 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0152016 Medline TA: Pharmacology Country: Switzerland |
Other Details:
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Languages: eng Pagination: 213-9 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2004 S. Karger AG, Basel. |
Affiliation:
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Department of Clinical Pharmacology, Niigata University of Pharmacy and Applied Life Sciences, Kamishinei-cho, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic alpha-Antagonists
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administration & dosage,
pharmacology* Adrenergic beta-Antagonists / administration & dosage, pharmacology* Algorithms Animals Blood Pressure / drug effects Carbazoles / administration & dosage, pharmacology* Electrocardiography / drug effects Heart / drug effects Heart Failure / physiopathology* Heart Rate / drug effects Hemodynamics / drug effects* Infusions, Intravenous Male Myocardium / metabolism Norepinephrine / blood Propanolamines / administration & dosage, pharmacology* Rats Rats, Inbred Lew Sympathetic Nervous System / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic alpha-Antagonists; 0/Adrenergic beta-Antagonists; 0/Carbazoles; 0/Propanolamines; 51-41-2/Norepinephrine; 72956-09-3/carvedilol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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