Document Detail

Hemodynamic effects of calcium-sensitizing agents.
MedLine Citation:
PMID:  8907128     Owner:  NLM     Status:  MEDLINE    
Over the last few years the development of calcium-sensitizing agents has led to a new approach to the treatment of congestive heart failure (CHF). These novel inotropic agents act directly on the contractile protein systems and correct the reduced responsiveness of the myofilaments to calcium. The resultant favorable inotropic activity of this new class of cardiotonic agents may represent an important pharmacologic approach to the future treatment of acute and chronic CHF. This brief review summarizes the cardiotonic effects of calcium sensitizers, with particular emphasis on the hemodynamic actions of these drugs in various in vitro and in vivo heart preparations. We also attempt to draw conclusions for the therapeutic exploitation of these agents and delineate their possible role in the therapy of CHF.
A Vegh; J G Papp; E Udvary; K Kaszala
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  26 Suppl 1     ISSN:  0160-2446     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:  1995  
Date Detail:
Created Date:  1997-03-05     Completed Date:  1997-03-05     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  S20-31     Citation Subset:  IM    
Department of Pharmacology, Albert Szent-Gyorgyi Medical University, Szeged, Hungary.
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MeSH Terms
Calcium / physiology*
Cardiotonic Agents / pharmacology*
Heart Failure / drug therapy
Hemodynamics / drug effects*
Myocardial Contraction / drug effects,  physiology
Phosphodiesterase Inhibitors / pharmacology
Sensitivity and Specificity
Reg. No./Substance:
0/Cardiotonic Agents; 0/Phosphodiesterase Inhibitors; 7440-70-2/Calcium

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