Document Detail


Hemodynamic effects of calcitonin gene-related peptide in spontaneously hypertensive rats.
MedLine Citation:
PMID:  2309935     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Systemic and regional hemodynamic effects of intravenously injected calcitonin gene-related peptide (CGRP), 220 and 650 pmol, were compared in nine Wistar-Kyoto (WKY) and nine spontaneously hypertensive rats (SHR). CGRP (higher dose) reduced mean arterial pressure (from 135 +/- 2 to 83 +/- 2 and from 179 +/- 4 to 116 +/- 3 mmHg; P less than 0.01, each, in WKY and SHR, respectively) through a fall (-38 +/- 4 and -40 +/- 3%; P less than 0.01) in total peripheral resistance associated with an unchanged cardiac output and an increased heart rate. The decreases in arterial pressure and total peripheral resistance were not different between these two strains. Of particular significance were the highly selective reductions in organ vascular resistances, being greatest in the cutaneous (-78 +/- 3 and -67 +/- 4%) and gastric (-80 +/- 3 and -84 +/- 2%) circulations in WKY and SHR, respectively (P less than 0.01). Reduction in coronary, cerebral, and hepatic vascular resistances, although significant (P less than 0.05, at least), were only moderately reduced compared with the two former circulations. These effects were similar in WKY and SHR and demonstrate that CGRP is a highly selective and potent natural vasodilating peptide that has the most striking effects in skin and stomach, suggesting possible modulator functions in regulating certain regional hemodynamics.
Authors:
K Ando; B L Pegram; E D Frohlich
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The American journal of physiology     Volume:  258     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1990 Feb 
Date Detail:
Created Date:  1990-04-03     Completed Date:  1990-04-03     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  R425-9     Citation Subset:  IM    
Affiliation:
Division of Research, Alton Ochsner Medical Foundation, New Orleans, Louisiana 70121.
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MeSH Terms
Descriptor/Qualifier:
Animals
Calcitonin Gene-Related Peptide / pharmacology*
Hemodynamics / drug effects*
Male
Rats
Rats, Inbred SHR
Rats, Inbred WKY
Regional Blood Flow / drug effects
Skin / blood supply
Stomach / blood supply
Chemical
Reg. No./Substance:
83652-28-2/Calcitonin Gene-Related Peptide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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