Document Detail

Hemodynamic effects of bufalin in the anesthetized dog.
MedLine Citation:
PMID:  2737715     Owner:  NLM     Status:  MEDLINE    
Studies in Lichstein's laboratory suggest that the endogenous digitalislike substance implicated in low renin hypertension might be a steroidal dienolide derivative. If this is true, the bufadienolides should block potassium vasodilation and enhance norepinephrine vasoconstriction, constrict blood vessels, raise blood pressure, and produce natriuresis and diuresis. We have therefore examined these parameters while infusing bufalin (aglycone), a bufadienolide, intrabrachially and intravenously in the anesthetized dog. Intrabrachial infusion of 5-25 micrograms/min with brachial arterial blood flow held constant at 100 ml/min produced a dose-dependent increase in perfusion pressure with rapid onset and offset, a progressive decrease in the vasodilator response to intrabrachial injection of 1 ml iso-osmotic potassium chloride solution (but not to acetylcholine), and an increase in the vasoconstrictor response to intrabrachial injection of 0.1 microgram norepinephrine. Intravenous infusion at 5-50 micrograms/min produced a dose-dependent increase in systemic arterial blood pressure, rate of change of ventricular pressure (dP/dt), and after the highest dose, cardiac irregularities. Natriuresis and diuresis were not observed. Thus, bufalin does in fact have some of the physiological properties required to be considered a candidate for the digitalislike substance found in low renin hypertension.
D Eliades; B Swindall; J Johnston; M Pamnani; F Haddy
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Hypertension     Volume:  13     ISSN:  0194-911X     ISO Abbreviation:  Hypertension     Publication Date:  1989 Jun 
Date Detail:
Created Date:  1989-08-08     Completed Date:  1989-08-08     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  690-5     Citation Subset:  IM    
Department of Physiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799.
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MeSH Terms
Brachial Artery
Bufanolides / pharmacology*
Chemical Phenomena
Forelimb / blood supply
Hemodynamics / drug effects*
Infusions, Intravenous
Injections, Intra-Arterial
Reg. No./Substance:
0/Bufanolides; 465-21-4/bufalin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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