Document Detail

Hemodynamic effects of atropine, dobutamine, nitroprusside, phenylephrine, and propranolol in conscious horses.
MedLine Citation:
PMID:  2061869     Owner:  NLM     Status:  MEDLINE    
The authors investigated the cardiovascular effects of low doses of nitroprusside, dobutamine, and phenylephrine and a beta-adrenergic blocking dose of propranolol in conscious, healthy horses with and without prior atropine administration. A parasympathetic blocking dose of atropine produced significant increases in heart rate and arterial pressures, and decreased stroke volume, ejection fraction, pulse pressure, and right-ventricular end-diastolic pressure and volume. Cardiac output was not changed by atropine administration. Nitroprusside reduced arterial pressures to a greater extent in atropinized horses but increased heart rate in both atropinized and non-atropinized horses. Dobutamine increased mean arterial pressure in both non-atropinized and atropinized horses but increased heart rate, diastolic arterial pressure, and systemic vascular resistance only in atropinized horses. Propranolol did not affect any of the hemodynamic variables that were measured. Phenylephrine, in the presence of beta-adrenergic blockade, increased mean arterial pressure and reduced cardiac output. This study showed that low doses of nitroprusside, dobutamine, and phenylephrine produce significant hemodynamic effects in conscious, healthy horses and that these effects are modified by prevailing parasympathetic tone.
K W Hinchcliff; K H McKeever; W W Muir
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of veterinary internal medicine / American College of Veterinary Internal Medicine     Volume:  5     ISSN:  0891-6640     ISO Abbreviation:  J. Vet. Intern. Med.     Publication Date:    1991 Mar-Apr
Date Detail:
Created Date:  1991-08-05     Completed Date:  1991-08-05     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8708660     Medline TA:  J Vet Intern Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  80-6     Citation Subset:  IM    
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Ohio State University, Columbus 43210.
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MeSH Terms
Atropine / pharmacology*
Blood Pressure / drug effects
Cardiac Output / drug effects
Cardiovascular Agents / pharmacology*
Dobutamine / pharmacology
Heart Rate / drug effects
Hemodynamics / drug effects*
Horses / physiology*
Nitroprusside / pharmacology
Phenylephrine / pharmacology
Propranolol / pharmacology
Stroke Volume / drug effects
Vascular Resistance / drug effects
Reg. No./Substance:
0/Cardiovascular Agents; 15078-28-1/Nitroprusside; 34368-04-2/Dobutamine; 51-55-8/Atropine; 525-66-6/Propranolol; 59-42-7/Phenylephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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