Document Detail


Hemodynamic effects of acute digitalization several months after acute myocardial infarction.
MedLine Citation:
PMID:  782704     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Left ventricular function was investigated at rest and during exercise by heart catheterization in 15 patients 3-5 months after acute myocardial infarction. The effect of 1 mg digoxin i.v. in ten patients was correlated to placebo (saline solution) in five patients. A significant decrease of the left ventricular enddiastolic pressure, increase of left ventricular systolic ejection fraction and a shift of the left ventricular function curve to left upwards was found after digoxin with no changes in the placebo group. This beneficial effect of acute digitalization in patients convalescing from uncomplicated myocardial infarction without clinical signs of manifest heart failure could have therapeutic implication.
Authors:
J Ressl; R Jandová; P Jebavý; J Kasalický; J Widimský
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Cardiology     Volume:  60     ISSN:  0008-6312     ISO Abbreviation:  Cardiology     Publication Date:  1975  
Date Detail:
Created Date:  1976-11-01     Completed Date:  1976-11-01     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  1266406     Medline TA:  Cardiology     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  321-8     Citation Subset:  IM; S    
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Adult
Aged
Blood Pressure / drug effects
Cardiac Output / drug effects
Clinical Trials as Topic
Digoxin / therapeutic use*
Drug Evaluation
Heart Rate / drug effects
Heart Ventricles / drug effects,  physiopathology
Hemodynamics / drug effects*
Humans
Male
Middle Aged
Myocardial Infarction / drug therapy*,  physiopathology
Physical Exertion
Chemical
Reg. No./Substance:
20830-75-5/Digoxin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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