Document Detail


Hemodynamic effects of acute and chronic administration of vapreotide in rats with cirrhosis.
MedLine Citation:
PMID:  12645803     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of this study was to assess the hemodynamic effects of acute and chronic administration of vapreotide, a somatostatin analog, in rats with intrahepatic portal hypertension induced by dimethylnitrosamine (DMNA) administration. Acute effects were evaluated at baseline and 30 min after placebo (N = 13) or vapreotide (8 /microg/kg/hr, N = 13) infusions in DMNA rats. Chronic hemodynamic effects were evaluated using subcutaneous implants for five weeks in anesthetized DMNA rats (placebo: N = 13, vapreotide: N = 13) and in sham rats (placebo: N = 10, vapreotide: N = 10). Hemodynamic measurements included splenorenal shunt blood flow (SRS BF) by the transit time ultrasound (TTU) method and cardiac output by the combined dilution-TTU method. Acute administration of vapreotide significantly decreased SRS BF (-17.3 +/- 19 vs - 1.1 +/- 14%, P < 0.05) and portal pressure (-8 +/- 9 vs 0 +/- 8%, p < 0.05) compared to placebo without systemic effects. Chronic administration of vapreotide significantly reduced the increase in SRS BF (2.4 +/- 1.5 vs 1.2 +/- 1.0 ml/min, P < 0.05) and cardiac index (50 +/- 15 vs 33 +/- 10 ml/min/100 g, P < 0.0001) while portal pressure and blood flow, and mean arterial pressure were not significantly changed compared to placebo. In conclusion, the acute administration of vapreotide decreased collateral circulation blood flow while chronic administration attenuated its development. Vapreotide seems to have a vasoconstrictive effect on collateral circulation.
Authors:
Nary Veal; Frédéric Moal; Frédéric Oberti; Eric Vuillemin; Paul Calés
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Digestive diseases and sciences     Volume:  48     ISSN:  0163-2116     ISO Abbreviation:  Dig. Dis. Sci.     Publication Date:  2003 Jan 
Date Detail:
Created Date:  2003-03-20     Completed Date:  2003-04-08     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7902782     Medline TA:  Dig Dis Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  154-61     Citation Subset:  AIM; IM    
Affiliation:
Laboratoire HIFIH, UPRES EA 2170, Université d'Angers, France.
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MeSH Terms
Descriptor/Qualifier:
Analgesics / pharmacology*
Animals
Collateral Circulation / drug effects
Hemodynamics / drug effects*
Hypertension, Portal / drug therapy*,  physiopathology
Liver Cirrhosis, Experimental / physiopathology*
Male
Rats
Rats, Sprague-Dawley
Somatostatin / analogs & derivatives*,  pharmacology*
Chemical
Reg. No./Substance:
0/Analgesics; 0/vapreotide; 51110-01-1/Somatostatin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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