| Hemodynamic effects of 1-[3,4-dihydroxyphenyl]-1,2-diaminoethane versus norepinephrine during ventricular fibrillation and cardiopulmonary resuscitation. | |
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MedLine Citation:
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PMID: 1965347 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We hypothesized that substitution of the hydroxyl group (OH) on the beta carbon of norepinephrine (NE) with an amino group would yield a compound, 1-(3,4-dihydroxyphenyl)-1,2-diaminoethane (DHPDAE), that would maintain the hemodynamic properties of NE during CPR, but would decrease the rate of post-defibrillation dysrhythmias. Six mixed breed swine weighing greater than 28 kg were studied. The animals were instrumented for cerebral (CBF) and myocardial blood flow (MBF) measurements. Ventricular fibrillation (VF) was induced. After 10 min of VF, CPR was begun. After 3 min of CPR, 2.5 mg/kg of DHPDAE was administered and CPR continued. Defibrillation was attempted 3.5 min after drug administration. CBF, MBF and defibrillation rates were compared to an historical control group receiving 0.16 mg/kg of NE. Outcome variables were compared using a Wilcoxon Rank Sum test and Fisher-exact test. NE significantly improved CBF and MBF compared to DHPDAE. All the animals in the NE group were successfully defibrillated into a perfusing rhythm. Sixty percent of the NE treated animals experienced post-defibrillation ventricular dysrhythmias. None of the animals in the DHPDAE were successfully defibrillated into a perfusing rhythm. Substitution of the hydroxyl group on the beta-carbon of NE with an amino group significantly decreases the hemodynamic properties of the parent molecule. |
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Authors:
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G D Nejman; R Griffith; P Van Ligten; J Hoekstra; L Casto; D D Miller; C G Brown |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Resuscitation Volume: 20 ISSN: 0300-9572 ISO Abbreviation: Resuscitation Publication Date: 1990 Dec |
Date Detail:
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Created Date: 1991-06-04 Completed Date: 1991-06-04 Revised Date: 2009-08-25 |
Medline Journal Info:
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Nlm Unique ID: 0332173 Medline TA: Resuscitation Country: IRELAND |
Other Details:
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Languages: eng Pagination: 243-52 Citation Subset: IM |
Affiliation:
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Division of Emergency Medicine, Ohio State University, Columbus 43210. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arrhythmias, Cardiac / prevention & control Cerebrovascular Circulation / drug effects Coronary Circulation / drug effects Electric Countershock* Epinephrine / analogs & derivatives*, therapeutic use Hemodynamics / drug effects* Norepinephrine / therapeutic use* Resuscitation* Swine Ventricular Fibrillation / therapy* |
| Chemical | |
Reg. No./Substance:
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132261-26-8/1-(3,4-dihydroxyphenyl)-1,2-diaminoethane; 51-41-2/Norepinephrine; 51-43-4/Epinephrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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