Document Detail


Hemodynamic effect of Neuroform stent on intimal hyperplasia and thrombus formation in a carotid aneurysm.
MedLine Citation:
PMID:  21233001     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Stents play an important role in management of cerebral aneurysms. A stent reconstructs the parent artery, assists coil embolization, and decreases flow activity within an aneurysm. However, an in-stent stenosis often occurs within the stented artery and compromises the circulation at the parent artery. Hemodynamic basis of re-stenoses from aneurysm stenting is not fully understood. An 8mm cavernous carotid aneurysm with a wide neck was treated by a Neuroform stent first and by coils five weeks later. A comparison of the difference in morphology during this five-week period reveals the presence of intimal hyperplasia in the internal carotid artery, 1.3mm thick at the proximal end and 1mm at the distal end of the stent, and 1mm thick thrombus at the postero-inferior side of the aneurysm. Computational fluid dynamic analyses show that the site of intimal hyperplasia is exposed to low wall shear with high oscillatory shear index (OSI), and the location of thrombus is subject to high OSI. Intimal hyperplasia and thrombus occur at comparable rates, but at different hemodynamic conditions; however, both prefer regions with high OSIs.
Authors:
Liang-Der Jou; Michel E Mawad
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-1-11
Journal Detail:
Title:  Medical engineering & physics     Volume:  -     ISSN:  1873-4030     ISO Abbreviation:  -     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-1-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9422753     Medline TA:  Med Eng Phys     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2010 IPEM. Published by Elsevier Ltd. All rights reserved.
Affiliation:
Department of Radiology, Baylor College of Medicine, 1 Baylor Plaza, MS-360, Houston, TX 77030, United States.
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