Document Detail


Hemodynamic characteristics of critical stenosis in canine coronary arteries.
MedLine Citation:
PMID:  1113539     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To determine the hemodynamic characteristics of critical stenosis of coronary arteries, mean left circumflex coronary artery (LCCA) flow, myocardial peak reactive hyperemic response (PRHR), myocardial PO2 and PCO2 electrocardiograms, and aortic pressure were monitored at precise degrees of LCCA stenosis in 18 dogs. Stepwise LCCA constriction by a specially designed occluder resulted in a gradual drop in PRHR but little change in other variables. When PRHR was reduced 96 per cent, critical stenosis was achieved, and further constriction caused pronounced and sudden changes in all parameters. When critical stenosis occurred, LCCA diameter had been reduced by 74 plus or minus 2 per cent. Mean LCCA flow was reduced from a base-line level of 42 plus or minus 2 to 34 plus or minus 2 c.c. per minute. PO2 in the myocardium was reduced from 24 plus or minus 1.5 to 16 plus or minus 1.6 mm. Hg. PCO2 increased from 43 plus or minus 5 to 55 plus or minus mm. Hg. T waves in Lead II because isoelectric. The myocardium was well perfused and able to regulate flow through an artery narrowed up to 74 per cent. Beyond this point of critical stenosis, the vascular bed was maximally dilated and further narrowing caused ischemia. These findings indicate that PRHR may be useful at operation to determiine whether all significant lesions are bypassed and whether graft flow is adequate.
Authors:
W E Elzinga; D B Skinner
Related Documents :
2617239 - Surgical management of congenital aortic stenosis in children and young adults.
22185529 - Obstetric haemorrhage uterine sepsis with uterine artery embolisation in the management...
11003759 - Surgery for bilateral outflow tract obstruction in elastin arteriopathy.
12218979 - Medical management versus investigate-and-operate strategy in asymptomatic carotid sten...
24704629 - Modest alcohol consumption and carotid plaques or carotid artery stenosis in men with n...
832349 - Variability in the analysis of coronary arteriograms.
7471829 - Tricuspid atresia with double-outlet left atrium.
21937239 - Traumatic occlusion and dissection of the main renal artery: endovascular treatment.
23978769 - Carotid artery atherosclerosis is correlated with cognitive impairment in an elderly ur...
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  The Journal of thoracic and cardiovascular surgery     Volume:  69     ISSN:  0022-5223     ISO Abbreviation:  J. Thorac. Cardiovasc. Surg.     Publication Date:  1975 Feb 
Date Detail:
Created Date:  1975-05-05     Completed Date:  1975-05-05     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0376343     Medline TA:  J Thorac Cardiovasc Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  217-22     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure
Carbon Dioxide / metabolism
Cardiac Output
Coronary Circulation*
Coronary Disease / metabolism,  physiopathology*
Dogs
Electrocardiography
Hemodynamics*
Myocardium / metabolism
Oxygen Consumption
Chemical
Reg. No./Substance:
124-38-9/Carbon Dioxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  An experimental model for studying myocardial ischemia. Correlation of hemodynamic performance and m...
Next Document:  Surgical treatment of chronic constrictive pericarditis using cardiopulmonary bypass.