Document Detail

Hemodynamic characteristics of critical stenosis in canine coronary arteries.
MedLine Citation:
PMID:  1113539     Owner:  NLM     Status:  MEDLINE    
To determine the hemodynamic characteristics of critical stenosis of coronary arteries, mean left circumflex coronary artery (LCCA) flow, myocardial peak reactive hyperemic response (PRHR), myocardial PO2 and PCO2 electrocardiograms, and aortic pressure were monitored at precise degrees of LCCA stenosis in 18 dogs. Stepwise LCCA constriction by a specially designed occluder resulted in a gradual drop in PRHR but little change in other variables. When PRHR was reduced 96 per cent, critical stenosis was achieved, and further constriction caused pronounced and sudden changes in all parameters. When critical stenosis occurred, LCCA diameter had been reduced by 74 plus or minus 2 per cent. Mean LCCA flow was reduced from a base-line level of 42 plus or minus 2 to 34 plus or minus 2 c.c. per minute. PO2 in the myocardium was reduced from 24 plus or minus 1.5 to 16 plus or minus 1.6 mm. Hg. PCO2 increased from 43 plus or minus 5 to 55 plus or minus mm. Hg. T waves in Lead II because isoelectric. The myocardium was well perfused and able to regulate flow through an artery narrowed up to 74 per cent. Beyond this point of critical stenosis, the vascular bed was maximally dilated and further narrowing caused ischemia. These findings indicate that PRHR may be useful at operation to determiine whether all significant lesions are bypassed and whether graft flow is adequate.
W E Elzinga; D B Skinner
Related Documents :
6179209 - Surgical enucleation of discrete sub-aortic stenosis.
12218979 - Medical management versus investigate-and-operate strategy in asymptomatic carotid sten...
1301249 - Reproducibility of measurements of coronary narrowings by videodensitometry and by digi...
10730739 - An unusual cause of tracheal stenosis.
16171669 - Unsuspected subglottic stenosis in a 5-year-old scheduled for elective surgery.
16261269 - Severe supravalvar aortic stenosis in familial homozygous hypercholesterolemia.
9219469 - Surgical treatment of coronary artery aneurysm after percutaneous transluminal coronary...
2768959 - Endoarterial treatment of acute ischemia of the limbs with urokinase. italian cooperati...
17539849 - Evaluation of the relationship between radiological abnormalities and both pulmonary fu...
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  The Journal of thoracic and cardiovascular surgery     Volume:  69     ISSN:  0022-5223     ISO Abbreviation:  J. Thorac. Cardiovasc. Surg.     Publication Date:  1975 Feb 
Date Detail:
Created Date:  1975-05-05     Completed Date:  1975-05-05     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0376343     Medline TA:  J Thorac Cardiovasc Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  217-22     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Blood Pressure
Carbon Dioxide / metabolism
Cardiac Output
Coronary Circulation*
Coronary Disease / metabolism,  physiopathology*
Myocardium / metabolism
Oxygen Consumption
Reg. No./Substance:
124-38-9/Carbon Dioxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  An experimental model for studying myocardial ischemia. Correlation of hemodynamic performance and m...
Next Document:  Surgical treatment of chronic constrictive pericarditis using cardiopulmonary bypass.