| Hemodynamic changes in splanchnic blood vessels in portal hypertension. | |
| | |
MedLine Citation:
|
PMID: 18484617 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Portal hypertension (PHT) is associated with a hyperdynamic state characterized by a high cardiac output, increased total blood volume, and a decreased splanchnic vascular resistance. This splanchnic vasodilation is a result of an important increase in local and systemic vasodilators (nitric oxide, carbon monoxide, prostacyclin, endocannabinoids, and so on), the presence of a splanchnic vascular hyporesponsiveness toward vasoconstrictors, and the development of mesenteric angiogenesis. All these mechanisms will be discussed in this review. To decompress the portal circulation in PHT, portosystemic collaterals will develop. The presence of these portosystemic shunts are responsible for major complications of PHT, namely bleeding from gastrointestinal varices, encephalopathy, and sepsis. Until recently, it was accepted that the formation of collaterals was due to opening of preexisting vascular channels, however, recent data suggest also the role of vascular remodeling and angiogenesis. These points are also discussed in detail. |
| | |
Authors:
|
Isabelle Colle; Anja M Geerts; Christophe Van Steenkiste; Hans Van Vlierberghe |
Related Documents
:
|
19867947 - The relation of the spleen to blood destruction and regeneration and to hemolytic jaund... 3234507 - Hypothalamo-hypophyseal portal blood sampling from laboratory rats. the effects of endo... 14641917 - The role of atp and adenosine in the control of hepatic blood flow in the rabbit liver ... 12874677 - Octreotide lowers gastric mucosal blood flow in normal and portal hypertensive stomachs. 6299307 - Characterization of the vasodilator action of antihypertensive drug budralazine. 21779677 - Improvement of a pcr test to diagnose infection by mansonella ozzardi. |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Anatomical record (Hoboken, N.J. : 2007) Volume: 291 ISSN: 1932-8494 ISO Abbreviation: Anat Rec (Hoboken) Publication Date: 2008 Jun |
Date Detail:
|
Created Date: 2008-05-22 Completed Date: 2008-06-27 Revised Date: 2009-12-16 |
Medline Journal Info:
|
Nlm Unique ID: 101292775 Medline TA: Anat Rec (Hoboken) Country: United States |
Other Details:
|
Languages: eng Pagination: 699-713 Citation Subset: IM |
Affiliation:
|
Department of Hepatology and Gastroenterology, Ghent University Hospital, Ghent, Belgium. isabelle.colle@ugent.be |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Biological Factors / physiology Carbon Monoxide / physiology Collateral Circulation / physiology Endocannabinoids / physiology Epoprostenol / physiology Hemodynamics Humans Hypertension, Portal / etiology, pathology, physiopathology* Liver Circulation / physiology Models, Cardiovascular Neovascularization, Pathologic Nitric Oxide / physiology Splanchnic Circulation / physiology* Vascular Endothelial Growth Factor A / physiology Vasodilation / physiology |
| Chemical | |
Reg. No./Substance:
|
0/Biological Factors; 0/Endocannabinoids; 0/Vascular Endothelial Growth Factor A; 0/endothelium-dependent hyperpolarization factor; 10102-43-9/Nitric Oxide; 35121-78-9/Epoprostenol; 630-08-0/Carbon Monoxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Regulation of sinusoidal perfusion in portal hypertension.
Next Document: Liver perfusion in sepsis, septic shock, and multiorgan failure.