Document Detail

Hemodynamic changes in postprandial state.
MedLine Citation:
PMID:  17375406     Owner:  NLM     Status:  MEDLINE    
Several experimental data suggest that single sugar intake may induce heart rate acceleration and blood pressure elevation as a result of sympathetic activation secondary to insulin response and from alterations in endothelial function due to activation of oxidative stress. These hemodynamic effects might be more marked in patients with arterial hypertension or metabolic disorders, in particular in hypertensive patients with diabetes. A high-fat load may also induce activation of oxidative stress and endothelial dysfunction. However, the long-term effect of repeated intake of single sugar and fat on blood pressure, oxidative stress, and endothelial function should be tested in controlled trials. On the contrary, a balanced mixed meal (50% carbohydrates) does not induce any significant blood pressure changes. Nevertheless, acarbose treatment is able to reduce hypertension incidence in patients with impaired glucose tolerance and to improve endothelial function. In elderly subjects, in particular with type 2 diabetes or with severe dysautonomia, sigle sugar intake may account for nonhypoglycemic postprandial dizziness.
P Valensi; E Cosson
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Diabetes & metabolism     Volume:  32 Spec No2     ISSN:  1262-3636     ISO Abbreviation:  Diabetes Metab.     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2007-03-21     Completed Date:  2007-05-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9607599     Medline TA:  Diabetes Metab     Country:  France    
Other Details:
Languages:  eng     Pagination:  2S37-41     Citation Subset:  IM    
Department of Endocrinology, Diabétology, Nutrition, Paris-Nord University, AP-HP, CRNH Ile-de-France, Bondy.
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MeSH Terms
Blood Pressure / drug effects*
Dietary Carbohydrates / pharmacology
Dietary Fats / pharmacology
Glucose / pharmacology
Models, Biological
Postprandial Period / physiology*
Reg. No./Substance:
0/Dietary Carbohydrates; 0/Dietary Fats; 50-99-7/Glucose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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