| Hemodynamic changes during protamine administration. | |
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MedLine Citation:
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PMID: 6603799 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hemodynamic responses to intravenous protamine sulfate in 40 patients were evaluated. The dose of protamine administered was calculated as adequate to reverse residual heparin as measured by the activated clotting time (ACT). Thirty patients (n = 30) received protamine at a rate of 0.5 mg/kg/min and the remainder (n = 10) received protamine at a rate of 1 mg/kg/min. Hemodynamic measurements were made before protamine, at 5-min intervals during administration, and 5 min after completion of the infusion. No statistically significant changes in cardiac output, systemic arterial blood pressure, or vascular resistance were seen when protamine was administered to patients with good left ventricular function after cardiopulmonary bypass. However, in patients with poor left ventricular function after cardiopulmonary bypass, protamine infusion was associated with systemic vasodilation that was only partially compensated for by an increase in cardiac index, resulting in a 12% decrease in mean blood pressure (P less than 0.05). Thus protamine should be administered cautiously to patients who have poor left ventricular function after cardiopulmonary bypass. |
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Authors:
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I A Michaels; P G Barash |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Anesthesia and analgesia Volume: 62 ISSN: 0003-2999 ISO Abbreviation: Anesth. Analg. Publication Date: 1983 Sep |
Date Detail:
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Created Date: 1983-09-20 Completed Date: 1983-09-20 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1310650 Medline TA: Anesth Analg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 831-5 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Pressure / drug effects Calcium Chloride / pharmacology Cardiac Output / drug effects Coronary Artery Bypass Female Heart Valve Prosthesis Hemodynamics / drug effects* Humans Male Middle Aged Protamines / adverse effects* Vascular Resistance / drug effects Whole Blood Coagulation Time |
| Chemical | |
Reg. No./Substance:
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0/Protamines; 10043-52-4/Calcium Chloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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