Document Detail

Hemodynamic changes during protamine administration.
MedLine Citation:
PMID:  6603799     Owner:  NLM     Status:  MEDLINE    
Hemodynamic responses to intravenous protamine sulfate in 40 patients were evaluated. The dose of protamine administered was calculated as adequate to reverse residual heparin as measured by the activated clotting time (ACT). Thirty patients (n = 30) received protamine at a rate of 0.5 mg/kg/min and the remainder (n = 10) received protamine at a rate of 1 mg/kg/min. Hemodynamic measurements were made before protamine, at 5-min intervals during administration, and 5 min after completion of the infusion. No statistically significant changes in cardiac output, systemic arterial blood pressure, or vascular resistance were seen when protamine was administered to patients with good left ventricular function after cardiopulmonary bypass. However, in patients with poor left ventricular function after cardiopulmonary bypass, protamine infusion was associated with systemic vasodilation that was only partially compensated for by an increase in cardiac index, resulting in a 12% decrease in mean blood pressure (P less than 0.05). Thus protamine should be administered cautiously to patients who have poor left ventricular function after cardiopulmonary bypass.
I A Michaels; P G Barash
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Anesthesia and analgesia     Volume:  62     ISSN:  0003-2999     ISO Abbreviation:  Anesth. Analg.     Publication Date:  1983 Sep 
Date Detail:
Created Date:  1983-09-20     Completed Date:  1983-09-20     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  1310650     Medline TA:  Anesth Analg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  831-5     Citation Subset:  AIM; IM    
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MeSH Terms
Blood Pressure / drug effects
Calcium Chloride / pharmacology
Cardiac Output / drug effects
Coronary Artery Bypass
Heart Valve Prosthesis
Hemodynamics / drug effects*
Middle Aged
Protamines / adverse effects*
Vascular Resistance / drug effects
Whole Blood Coagulation Time
Reg. No./Substance:
0/Protamines; 10043-52-4/Calcium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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