Document Detail

Hemodynamic changes as a diagnostic tool in acute heart failure-a pilot study.
MedLine Citation:
PMID:  21030189     Owner:  NLM     Status:  In-Data-Review    
OBJECTIVES: To examine whether posturally induced changes in cardiac output differentiate patients presenting with dyspnea to the emergency department (ED) with acute heart failure (AHF) from other causes.
METHODS: This was an observational study of patients presenting to the ED with dyspnea. Exclusion criteria included ischemic chest pain, electrocardiographic changes diagnostic of acute myocardial infarction, pericardial effusion or chest wall deformities causing dyspnea, or heart transplant. Hemodynamic variables of cardiac index (CI), total peripheral resistance index, and thoracic fluid content (TFC) were determined in upright seated and supine positions 3 minutes apart using bioreactance technology (Cheetah Medical Inc, Portland, Ore). Acute heart failure was defined as either B-type natriuretic peptide 100 to 500 pg/mL and discharge diagnosis of AHF or a B-type natriuretic peptide greater than 500 pg/mL.
RESULTS: Of 92 patients, 25 had AHF, 23 had asthma/chronic obstructive pulmonary disease (COPD), and 44 had dyspnea related to other conditions; 41 (44.1%) were male, 56 (60.2%) were African American, and the mean age was 58 ± 15.0 years. Mean baseline TFC was higher in AHF vs asthma/COPD (59.3 ± 26.0 vs 39.7 ± 14.8 1/kW, P = .003) and trended higher compared to other patients with dyspnea (49.2 ± 22.0, P = .10). Postural changes in mean CI were lower in AHF (-0.20 ± 0.84 L min(-1) m(-2)) vs asthma/COPD (1.20 ± 1.23 L min(-1) m(-2); P = .002) and other dyspnea patients (0.82 ± 0.91 L min(-1) m(-2); P = .007).
CONCLUSION: Patients with AHF have greater TFC but lower CI responses to postural changes compared to patients with asthma and COPD. Knowledge of these changes may help rapidly differentiate AHF from asthma and COPD in the ED.
Rakesh S Engineer; Justin L Benoit; Caitlin W Hicks; Sunny J Kolattukudy; Daniel Burkhoff; W Frank Peacock
Related Documents :
17964349 - Human atrial natriuretic peptide and nicorandil as adjuncts to reperfusion treatment fo...
19804159 - Current and future uses of nesiritide.
18513509 - Comparison of matrix metalloproteinase 9 and brain natriuretic peptide as clinical biom...
10520779 - Angiotensin-converting enzyme inhibition reduces monocyte chemoattractant protein-1 and...
3303889 - Heterogeneous myocardial catecholamine concentrations in patients with congestive heart...
12371769 - Changes in concentrations of neuroendocrine hormones and catecholamines in dogs with my...
1610229 - Early structural deterioration with the mitroflow pericardial xenograft in the mitral p...
12655279 - Vascular endothelial function in patients with slow coronary flow.
12396229 - New approaches to atrial fibrillation management: a critical review of a rapidly evolvi...
Publication Detail:
Type:  Journal Article     Date:  2010-10-27
Journal Detail:
Title:  The American journal of emergency medicine     Volume:  30     ISSN:  1532-8171     ISO Abbreviation:  Am J Emerg Med     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2011-11-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8309942     Medline TA:  Am J Emerg Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  174-80     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Emergency Services Institute/E-19, Cleveland Clinic, Cleveland, OH 44195, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Recombinant tissue plasminogen activator for both pulmonary and cerebral embolism.
Next Document:  The need for dental care among adults presenting to an urban ED.