| Hemodynamic and autonomic effects of smokeless tobacco in healthy young men. | |
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MedLine Citation:
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PMID: 15766828 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: The aim of this study was to investigate the acute hemodynamic and autonomic effects of smokeless tobacco. BACKGROUND: Smokeless tobacco use is increasing. Its cardiovascular effects are not well understood. METHODS: Sixteen healthy, male, habitual snuff tobacco users (aged 22 +/- 1 year) were studied, using a randomized, double-blind, placebo-controlled, crossover design with two separate experimental sessions: placebo and tobacco. Muscle sympathetic nerve activity (MSNA), electrocardiogram, blood pressure, calf blood flow, nicotine, and catecholamines were measured. RESULTS: Snuff tobacco increased plasma nicotine from 2.8 +/- 0.5 ng/ml to 10.4 +/- 1.1 ng/ml. Mean blood pressure increased by 10 +/- 1 mm Hg, and heart rate increased by 16 +/- 2 beats/min. Peripheral vascular resistance, MSNA, and norepinephrine concentration did not change with tobacco, but epinephrine increased by approximately 50%. CONCLUSIONS: Oral snuff tobacco increases heart rate, blood pressure, and epinephrine. Despite the increase in blood pressure, there is no decrease in either MSNA or peripheral vascular resistance. Smokeless tobacco is a powerful autonomic and hemodynamic stimulus. Catecholamine release from the adrenal medulla likely contributes to this response. |
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Authors:
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Robert Wolk; Abu S M Shamsuzzaman; Anna Svatikova; Christine M Huyber; Corey Huck; Krzysztof Narkiewicz; Virend K Somers |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of the American College of Cardiology Volume: 45 ISSN: 0735-1097 ISO Abbreviation: J. Am. Coll. Cardiol. Publication Date: 2005 Mar |
Date Detail:
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Created Date: 2005-03-15 Completed Date: 2005-06-28 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8301365 Medline TA: J Am Coll Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 910-4 Citation Subset: AIM; IM |
Affiliation:
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Mayo Clinic, Rochester, Minnesota 55905, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Autonomic Nervous System / drug effects* Biological Markers / blood Blood Flow Velocity / drug effects Blood Pressure / drug effects Cross-Over Studies Double-Blind Method Electrocardiography Epinephrine / metabolism Heart Rate / drug effects Hemodynamics / drug effects* Humans Male Muscle, Skeletal / drug effects Norepinephrine / metabolism Reference Values Sympathetic Nervous System / drug effects Tobacco, Smokeless / adverse effects* Vascular Resistance / drug effects |
| Grant Support | |
ID/Acronym/Agency:
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3F05-TW-05200/TW/FIC NIH HHS; HL-61560/HL/NHLBI NIH HHS; HL-65176/HL/NHLBI NIH HHS; HL-70302/HL/NHLBI NIH HHS; M01-RR00585/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 51-41-2/Norepinephrine; 51-43-4/Epinephrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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