Document Detail


Hemodynamic and autonomic effects of smokeless tobacco in healthy young men.
MedLine Citation:
PMID:  15766828     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: The aim of this study was to investigate the acute hemodynamic and autonomic effects of smokeless tobacco. BACKGROUND: Smokeless tobacco use is increasing. Its cardiovascular effects are not well understood. METHODS: Sixteen healthy, male, habitual snuff tobacco users (aged 22 +/- 1 year) were studied, using a randomized, double-blind, placebo-controlled, crossover design with two separate experimental sessions: placebo and tobacco. Muscle sympathetic nerve activity (MSNA), electrocardiogram, blood pressure, calf blood flow, nicotine, and catecholamines were measured. RESULTS: Snuff tobacco increased plasma nicotine from 2.8 +/- 0.5 ng/ml to 10.4 +/- 1.1 ng/ml. Mean blood pressure increased by 10 +/- 1 mm Hg, and heart rate increased by 16 +/- 2 beats/min. Peripheral vascular resistance, MSNA, and norepinephrine concentration did not change with tobacco, but epinephrine increased by approximately 50%. CONCLUSIONS: Oral snuff tobacco increases heart rate, blood pressure, and epinephrine. Despite the increase in blood pressure, there is no decrease in either MSNA or peripheral vascular resistance. Smokeless tobacco is a powerful autonomic and hemodynamic stimulus. Catecholamine release from the adrenal medulla likely contributes to this response.
Authors:
Robert Wolk; Abu S M Shamsuzzaman; Anna Svatikova; Christine M Huyber; Corey Huck; Krzysztof Narkiewicz; Virend K Somers
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of the American College of Cardiology     Volume:  45     ISSN:  0735-1097     ISO Abbreviation:  J. Am. Coll. Cardiol.     Publication Date:  2005 Mar 
Date Detail:
Created Date:  2005-03-15     Completed Date:  2005-06-28     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8301365     Medline TA:  J Am Coll Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  910-4     Citation Subset:  AIM; IM    
Affiliation:
Mayo Clinic, Rochester, Minnesota 55905, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Autonomic Nervous System / drug effects*
Biological Markers / blood
Blood Flow Velocity / drug effects
Blood Pressure / drug effects
Cross-Over Studies
Double-Blind Method
Electrocardiography
Epinephrine / metabolism
Heart Rate / drug effects
Hemodynamics / drug effects*
Humans
Male
Muscle, Skeletal / drug effects
Norepinephrine / metabolism
Reference Values
Sympathetic Nervous System / drug effects
Tobacco, Smokeless / adverse effects*
Vascular Resistance / drug effects
Grant Support
ID/Acronym/Agency:
3F05-TW-05200/TW/FIC NIH HHS; HL-61560/HL/NHLBI NIH HHS; HL-65176/HL/NHLBI NIH HHS; HL-70302/HL/NHLBI NIH HHS; M01-RR00585/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers; 51-41-2/Norepinephrine; 51-43-4/Epinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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