Document Detail

Hemodynamic and autonomic effects of intravenous saterinone in patients with chronic heart failure.
MedLine Citation:
PMID:  9213204     Owner:  NLM     Status:  MEDLINE    
In this study, the hemodynamic and neurohumoral/autonomic effects of intravenous saterinone (a selective phosphodiesterase type III inhibitor, with additional alpha 1-blocking properties) were evaluated. In a double-blind, placebo-controlled design, 36 patients with moderate to severe heart failure were studied (saterinone, n = 24; placebo, n = 12). Invasive hemodynamic measurements, by using right-heart catheterization, were performed, as well as measurement of plasma neurohormones and analysis of heart rate variability (HRV), to study drug influences on neurohumoral activation and autonomic tone. Systemic vascular resistance significantly decreased during saterinone infusion, accompanied by a decrease in systemic blood pressure (both p values < 0.05) and an increase in heart rate (p = 0.05). Filling pressures also decreased during saterinone, but this was statistically significant only for pulmonary capillary wedge pressure, whereas the cardiac index remained unaffected. Plasma neurohormones (norepinephrine, epinephrine, and renin activity) were not significantly influenced by saterinone. HRV analysis revealed no significant effect of saterinone on autonomic tone. These results suggest that intravenous saterinone has a significant vasodilating effect in patients with moderate to severe chronic heart failure (CHF), without exerting an adverse effect on the autonomic nervous system, as demonstrated by assessment of plasma neurohormones and HRV analysis.
B M Szabó; D J van Veldhuisen; R B van Dijk; A Lahiri; V Mitrovic; K Stolzenburg; J Brouwer; K I Lie
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  29     ISSN:  0160-2446     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:  1997 May 
Date Detail:
Created Date:  1997-09-03     Completed Date:  1997-09-03     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  618-23     Citation Subset:  IM    
Department of Cardiology/Thoraxcenter, University Hospital Groningen, The Netherlands.
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MeSH Terms
Autonomic Nervous System / drug effects*
Double-Blind Method
Electrocardiography / drug effects
Heart Failure / drug therapy*,  physiopathology*
Heart Rate / drug effects
Hemodynamics / drug effects*
Injections, Intravenous
Middle Aged
Neurotransmitter Agents / blood
Phosphodiesterase Inhibitors / administration & dosage,  therapeutic use*
Piperazines / administration & dosage,  therapeutic use*
Pyridones / administration & dosage,  therapeutic use*
Reg. No./Substance:
0/Neurotransmitter Agents; 0/Phosphodiesterase Inhibitors; 0/Piperazines; 0/Pyridones; 102669-89-6/saterinone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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