Document Detail

Hemodynamic assessment of local anesthetic administration by laser Doppler flowmetry.
MedLine Citation:
PMID:  11346729     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The hemodynamic effects of local anesthetic administration with and without a vasoconstrictor were compared by using laser Doppler flowmetry. STUDY DESIGN: Seventeen people participated in a single study session in which they were given 2 intraoral injections. The injections, which were administered in random order, consisted of 1.8 mL lidocaine (2%) with epinephrine (1:100,000) and mepivacaine (3%). Hemodynamic parameters consisting of blood pressure, heart rate, and laser Doppler flowmetry were reordered at regular intervals. RESULTS: The laser Doppler flowmeter detected changes in the peripheral perfusion of the finger that were not detected by changes in blood pressure and heart rate. The greatest change was associated with anxiety and occurred just before the injection. The inclusion of epinephrine in the local anesthetic resulted in a persistence of these changes. CONCLUSION: This investigation has confirmed the sensitivity of laser Doppler flowmetry as an investigational tool for assessing hemodynamic changes associated with anxiety and the administration of local anesthesia.
E M Fernieini; J D Bennett; D G Silverman; T M Halaszynski
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics     Volume:  91     ISSN:  1079-2104     ISO Abbreviation:  Oral Surg Oral Med Oral Pathol Oral Radiol Endod     Publication Date:  2001 May 
Date Detail:
Created Date:  2001-05-10     Completed Date:  2001-07-19     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9508562     Medline TA:  Oral Surg Oral Med Oral Pathol Oral Radiol Endod     Country:  United States    
Other Details:
Languages:  eng     Pagination:  526-30     Citation Subset:  D; IM    
School of Dental Medicine, University of Connecticut, 263 Farmington Ave., Farmington, CT 06030, USA.
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MeSH Terms
Anesthetics, Local / administration & dosage*
Blood Pressure / drug effects*
Dental Anxiety / physiopathology
Double-Blind Method
Epinephrine / administration & dosage
Fingers / blood supply
Heart Rate / drug effects*
Laser-Doppler Flowmetry*
Lidocaine / administration & dosage
Mepivacaine / administration & dosage
Nerve Block
Regional Blood Flow / drug effects
Sensitivity and Specificity
Statistics as Topic
Vasoconstrictor Agents / administration & dosage
Reg. No./Substance:
0/Anesthetics, Local; 0/Vasoconstrictor Agents; 137-58-6/Lidocaine; 51-43-4/Epinephrine; 96-88-8/Mepivacaine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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