Document Detail

Hemodynamic assessment of ischemic stroke with near-infrared spectroscopy.
MedLine Citation:
PMID:  11543057     Owner:  NASA     Status:  MEDLINE    
OBJECTIVE: To validate near-infrared cerebral topography (NCT) as a practical tool in tracing the regional hemodynamic changes during normal ischemic stroke model of rat. METHOD: Middle cerebral artery occlusion (MCAO) and photosensitizer induced intracranial infarction model of rat were established. The geometric shape and infarction area were measured by NCT, functional magnetic resonance imaging (fMRI), and TTC stained anatomical imaging techniques. RESULT: In photosensitizer induced infarction model, the correlation between anatomical infarct area and NCT image area for infarct focus were r = 0.897 for 24 h group (P < 0.05) and r = 0.906 for 2 months group (P < 0.01), respectively. The correlation between anatomical infarction area and NCT image area for infarct focus were r = 0.820 for normothermia group (P < 0.05) and r = 0.851 for hypothermia group (P < 0.05), respectively. The correlation between fMRI and NCT image area for infarction focus were r = 0.874 for normothermia group (P < 0.05) and r = 0.782 for hypothermia group (P < 0. 05), respectively. CONCLUSION: Measurement with NCT for infarction focus matched well with fMRI and anatomic sample in rats. NCT technique might be a practical tool for short-term prediction of stroke and the rehabilitation after stroke in real time.
W G Chen; P C Li; Q M Luo; S Q Zeng; B Hu
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hang tian yi xue yu yi xue gong cheng = Space medicine & medical engineering     Volume:  13     ISSN:  1002-0837     ISO Abbreviation:  Space Med Med Eng (Beijing)     Publication Date:  2000 Apr 
Date Detail:
Created Date:  2000-06-29     Completed Date:  2000-06-29     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  9425305     Medline TA:  Space Med Med Eng (Beijing)     Country:  CHINA    
Other Details:
Languages:  eng     Pagination:  84-9     Citation Subset:  S    
Institute of Biomedical Photonics, Huazhong University of Science & Technology, Wuhan, China.
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MeSH Terms
Brain / blood supply,  metabolism,  pathology
Brain Ischemia / diagnosis*,  pathology
Cerebral Infarction / diagnosis*,  pathology
Disease Models, Animal
Hemodynamics / physiology*
Hemoglobins / metabolism
Hypothermia, Induced
Magnetic Resonance Imaging
Middle Cerebral Artery
Predictive Value of Tests
Rats, Sprague-Dawley
Spectroscopy, Near-Infrared / methods*
Stroke / diagnosis,  pathology,  prevention & control*
Reg. No./Substance:

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