Document Detail

Hemodynamic and arrhythmogenic effects of aversive stress during myocardial ischemia.
MedLine Citation:
PMID:  2341697     Owner:  NLM     Status:  MEDLINE    
Pavlovian conditioning was accomplished in two groups of dogs by following a 30-s tone (the CS+) with a short (less than or equal to 1 s) electric shock). An inflatable occluder was implanted around the left circumflex coronary artery in all animals. The CS+ was presented to Group I dogs (n = 6) during control (i.e., no coronary occlusion) and at 30 s and 3 min after the onset of a 4-min left circumflex coronary occlusion. The CS+ evoked a robust increase in heart rate and blood pressure in the control state. A conditional cardiovascular response was still evoked during the acute coronary occlusion despite the evolving myocardial ischemia. No increase in ventricular ectopic beats occurred during the CS+. An anterior myocardial infarction (16.8 +/- 1.7% of left ventricular mass, mean +/- SEM) was created in Group II dogs (n = 8) at the time of surgery. A CS+ was presented, as above, both alone and 1 min after the beginning of a 2-min left circumflex coronary occlusion. There were significant differences in the conditional response in heart rate, left ventricular (systolic) pressure (LVP) and d(LVP)/dt for trials given during the coronary occlusion compared with no occlusion. These dogs were then classified as 'resistant' or 'susceptible' to ventricular arrhythmias approx. 4 weeks later using an exercise and coronary occlusion test. Three of five susceptible dogs, but none of three resistant dogs, evidenced increased severity of arrhythmias during the CS+. We conclude that the nature of the cardiovascular response to behavioral stress during myocardial ischemia depends in part upon the timing of the CS+, the presence or absence of a resident myocardial infarction and the status of the autonomic reflexes controlling the heart.
G E Billman; D C Randall; D R Brown; S K Hall; J F Zolman
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of the autonomic nervous system     Volume:  29     ISSN:  0165-1838     ISO Abbreviation:  J. Auton. Nerv. Syst.     Publication Date:  1990 Mar 
Date Detail:
Created Date:  1990-06-26     Completed Date:  1990-06-26     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8003419     Medline TA:  J Auton Nerv Syst     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  193-202     Citation Subset:  IM    
Department of Physiology, Ohio State University, Columbus.
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MeSH Terms
Blood Pressure
Conditioning, Classical
Coronary Disease / complications,  physiopathology*
Heart Rate
Stress, Psychological / complications,  physiopathology*
Grant Support

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