Document Detail

[Hemodynamic and antipyretic effects of paracetamol, metamizol and dexketoprofen in critical patients].
MedLine Citation:
PMID:  22425338     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The objective was to study the antipyretic and hemodynamic effects of three different drugs used to treat fever in critically ill patients.
DESIGN AND SETTING: Prospective, observational study in a 16-bed, general ICU of a university hospital.
PATIENT POPULATION: We studied 150 patients who had a febrile episode (temperature>38°C): 50 received paracetamol, 50 metamizol and 50 dexketoprofen.
INTERVENTIONS: None. Body temperature, systolic, diastolic and mean arterial pressure, heart rate, central venous pressure and oxygen saturation were determined at baseline and at 30, 60 and 120minutes after infusion of the drug. Additionally, we recorded temperature 180minutes after starting drug infusion. Diuresis and the need for or change of dose of vasodilator or vasoconstrictor drugs were also recorded.
RESULTS: Patient characteristics, baseline temperature and hemodynamics were similar in all groups. We observed a significant decrease of at least 1°C in temperature after 180minutes in 38 patients treated with dexketoprofen (76%), in 36 with metamizol (72%), and in 20 with paracetamol (40%) (p<0.001). After 120minutes, the mean decrease in mean arterial pressure was 8.5±13.6mmHg with paracetamol, 14.9±11.8mmHg with metamizol, and 16.8±13.7mmHg with dexketoprofen (p=0.005).
CONCLUSIONS: Dexketoprofen was the most effective antipyretic agent at the doses tested. Although all three drugs reduced mean arterial pressure, the reduction with paracetamol was less pronounced.
P Vera; L Zapata; I Gich; J Mancebo; A J Betbesé
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Publication Detail:
Type:  English Abstract; Journal Article; Observational Study     Date:  2012-03-16
Journal Detail:
Title:  Medicina intensiva / Sociedad Española de Medicina Intensiva y Unidades Coronarias     Volume:  36     ISSN:  1578-6749     ISO Abbreviation:  Med Intensiva     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-26     Completed Date:  2014-02-03     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  9207689     Medline TA:  Med Intensiva     Country:  Spain    
Other Details:
Languages:  spa     Pagination:  619-25     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier España, S.L. and SEMICYUC. All rights reserved.
Vernacular Title:
Efectos hemodinámicos y antipiréticos del paracetamol, metamizol y dexketoprofeno en pacientes críticos.
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MeSH Terms
Acetaminophen / pharmacology*,  therapeutic use
Aged, 80 and over
Anti-Inflammatory Agents, Non-Steroidal / pharmacology*,  therapeutic use
Antipyretics / pharmacology*,  therapeutic use
Critical Illness
Dipyrone / pharmacology*,  therapeutic use
Fever / drug therapy*
Hemodynamics / drug effects*
Ketoprofen / analogs & derivatives*,  pharmacology,  therapeutic use
Middle Aged
Prospective Studies
Tromethamine / pharmacology*,  therapeutic use
Young Adult
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Antipyretics; 023C2WHX2V/Tromethamine; 362O9ITL9D/Acetaminophen; 68-89-3/Dipyrone; 90Y4QC304K/Ketoprofen; N674F7L21E/dexketoprofen trometamol

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