Document Detail


Hemodynamic and antihypertensive effects of captopril, an orally active angiotensin converting enzyme inhibitor.
MedLine Citation:
PMID:  232084     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Captopril inhibits angiotensin II formation and bradykinin degradation in vivo. Eleven patients with essential hypertension (EH) and four patients with renovascular hypertension (RVH) were treated with captopril for periods ranging from 3 days to 12 months. All patients had a diastolic blood pressure (DBP) over 95 mm Hg after receiving a placebo for 3 days. Captopril given in ascending doses (10-1000 mg/day) caused normalization of blood pressure in all but three patients, one with severe RVH whose pressure fell 11%, one patient with severe EH, whose pressure fell 27%, and one with EH whose blood pressure fell 8.5%. The average control DBP in patients with EH was 113.7 +/- 5.5 (SE) mm Hg and fell to 89.9 +/- 3.6 mm Hg (p less than 0.001), while DBP in patients with RVH fell from 110.7 +/- 7.6 mm Hg to 94.5 +/- 8.2 (p less than 0.005). All patients were studied in balance on a 100 mEq sodium (Na) diet. Plasma renin activity (PRA) versus 24-hour urinary Na excretion increased sevenfold during therapy while converting enzyme activity fell by about one half. The magnitude of the blood pressure response was not related to control PRA. Cardiac output was estimated by echocardiography during placebo administration and during maintenance therapy with captopril. A significant change was not observed. Total peripheral resistance fell an average of 18.9% (p less than 0.05) in 11 of the 13 patients in whom the measurement could be made. It is concluded that captopril effectively lowers blood pressure in patients with EH or RHV by reducing total peripheral resistance.
Authors:
J M Sullivan; B A Ginsburg; T E Ratts; J G Johnson; B R Barton; D H Kraus; D N McKinstry; E E Muirhead
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Hypertension     Volume:  1     ISSN:  0194-911X     ISO Abbreviation:  Hypertension     Publication Date:    1979 Jul-Aug
Date Detail:
Created Date:  1980-06-16     Completed Date:  1980-06-16     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  397-401     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Angiotensin-Converting Enzyme Inhibitors*
Blood Pressure / drug effects
Captopril / administration & dosage,  adverse effects,  pharmacology*
Drug Evaluation
Female
Hemodynamics / drug effects*
Humans
Hydrocortisone / blood
Hypertension / blood,  drug therapy*
Hypertension, Renovascular / blood,  drug therapy
Male
Middle Aged
Potassium / metabolism
Proline / analogs & derivatives*
Renin / blood
Sodium / metabolism
Chemical
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 147-85-3/Proline; 50-23-7/Hydrocortisone; 62571-86-2/Captopril; 7440-09-7/Potassium; 7440-23-5/Sodium; EC 3.4.23.15/Renin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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