Document Detail

Hemodynamic alterations in isoproterenol-induced cardiac arrhythmias in corticoid-treated rats.
MedLine Citation:
PMID:  702287     Owner:  NLM     Status:  MEDLINE    
Hemodynamic alterations were studied to determine their role in isoproterenol-induced cardiac arrhythmias in the desoxycorticosterone acetate--saline-treat rat. Since epinephrine, a catecholamine possessing an alpha-adrenergic receptor agonist component, was considerably less potent as an arrhythmogenic agent, an elevation in blood pressure was thought to be protective against arrhythmias. Both albuterol, a beta2-adrenergic agonist, alone and epinephrine administered following tolazoline, an alpha-adrenergic blocking agent, decreased blood pressure to that of isoproterenol but failed to elicit significant arrhythmias. Phenylephrine administered prior to isoproterenol resulted in significant arrhythmias despite the maintenance of mean blood pressure at normal levels. The study shows that blood pressure alterations are not important in the etiology of isoproterenol-induced arrhythmias in the corticoid-pretreated rat.
M A Barletta; D Lehr; G Guideri
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pharmaceutical sciences     Volume:  67     ISSN:  0022-3549     ISO Abbreviation:  J Pharm Sci     Publication Date:  1978 Oct 
Date Detail:
Created Date:  1978-12-29     Completed Date:  1978-12-29     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  2985195R     Medline TA:  J Pharm Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1390-4     Citation Subset:  IM    
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MeSH Terms
Adrenal Cortex Hormones / pharmacology*
Albuterol / pharmacology
Arrhythmias, Cardiac / chemically induced,  physiopathology*
Blood Pressure / drug effects
Desoxycorticosterone / pharmacology
Drug Interactions
Epinephrine / pharmacology
Heart Rate / drug effects
Hemodynamics / drug effects*
Isoproterenol / pharmacology*
Phenylephrine / pharmacology
Reg. No./Substance:
0/Adrenal Cortex Hormones; 18559-94-9/Albuterol; 51-43-4/Epinephrine; 59-42-7/Phenylephrine; 64-85-7/Desoxycorticosterone; 7683-59-2/Isoproterenol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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