Document Detail

Hemodynamic alterations in alcohol-related transitory hypertension.
MedLine Citation:
PMID:  8836328     Owner:  NLM     Status:  MEDLINE    
Alcoholic patients are often transiently hypertensive (tHT) during days 1-3 of withdrawal but become normotensive thereafter. However, at 3-4 weeks postwithdrawal these tHT patients may still show exaggerated blood pressure rises to isometric handgrip exercise. We examined the hemodynamic mechanisms associated with persistent altered pressure response. Forty-two alcoholic inpatients were equally divided into three subgroups based on admission BPs: transitory hypertensive (tHT;BP > or = 160/95 mmHg), transitory borderline hypertensive (tBH; 140/ 90 < or = BP < 160/95), and normotensive (NT; BP < 140/90). After 3-4 weeks of sobriety, the alcoholics and a normotensive nonalcoholic group (CONTs; n = 14) were tested during rest and an isometric handgrip task. Impedance cardiographic evaluation at both times showed elevated peripheral resistance, elevated heart rate, and reduced stroke volume in tHTs. Liquor consumption was found to be highly predictive of the altered hemodynamic and BP activity. Alcoholic patients with acute withdrawal hypertension (1-3 days) may show a persistent alteration of BP regulation even when resting pressures are normal.
A C King; N C Bernardy; O A Parsons; W R Lovallo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Alcohol (Fayetteville, N.Y.)     Volume:  13     ISSN:  0741-8329     ISO Abbreviation:  Alcohol     Publication Date:    1996 Jul-Aug
Date Detail:
Created Date:  1997-04-29     Completed Date:  1997-04-29     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8502311     Medline TA:  Alcohol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  387-93     Citation Subset:  IM    
Behavioral Sciences Laboratories, University of Oklahoma Health Sciences Center, Oklahoma City 73106, USA.
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MeSH Terms
Alcoholism / complications*
Blood Pressure
Exercise / physiology
Hand Strength
Health Status
Heart Rate
Hypertension / etiology*,  physiopathology*
Regression Analysis
Stroke Volume
Grant Support
C1212803//PHS HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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