Document Detail

Hemodynamic alterations in the acute retinal necrosis syndrome.
MedLine Citation:
PMID:  8341497     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Clinical and histopathologic observations suggest a role for ischemia in the pathogenesis of the acute retinal necrosis (ARN) syndrome. Disruption of blood flow appears to occur at some level in the retina or choroid and may account for some of the major features of the syndrome. METHODS: To investigate these potential circulatory changes, color Doppler imaging (CDI) was used to quantitate blood flow velocities and vascular resistance in the central retinal, ophthalmic, and short posterior ciliary arteries in ten consecutive patients with unilateral ARN syndrome. Data were analyzed with a paired Student's t test. The unaffected fellow eyes served as controls. RESULTS: Blood flow velocities within the central retinal artery were significantly reduced in eyes with ARN syndrome compared with control eyes. In affected eyes, there was a mean reduction of 55%, 60%, and 72% in peak systolic, average, and end-diastolic velocities, respectively (P < 0.01). The calculated vascular resistance of the central retinal artery showed an upward trend, but the data fell short of statistical significance. Blood flow velocities from the ophthalmic and short posterior ciliary arteries were not significantly different compared with controls. CONCLUSIONS: This study demonstrates marked circulatory changes in the central retinal artery of eyes involved with the ARN syndrome. Although the exact mechanism and clinical significance are yet to be determined, the data support the presence of retinal arterial hemodynamic compromise in this condition.
C D Regillo; R C Sergott; A C Ho; J B Belmont; D H Fischer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Ophthalmology     Volume:  100     ISSN:  0161-6420     ISO Abbreviation:  Ophthalmology     Publication Date:  1993 Aug 
Date Detail:
Created Date:  1993-08-30     Completed Date:  1993-08-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7802443     Medline TA:  Ophthalmology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1171-6     Citation Subset:  IM    
Retina Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA 19107.
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MeSH Terms
Aged, 80 and over
Blood Flow Velocity
Choroid / blood supply
Ciliary Body / blood supply
Middle Aged
Ophthalmic Artery / physiopathology
Prospective Studies
Pulsatile Flow
Retinal Artery / physiopathology*,  ultrasonography
Retinal Necrosis Syndrome, Acute / physiopathology*,  ultrasonography
Vascular Resistance

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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