Document Detail

Hemodynamic alterations during orthotopic liver experimental transplantation in pigs.
MedLine Citation:
PMID:  18372958     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To describe the hemodynamic alterations during orthotopic liver transplantation in pigs. METHODS: In the period from April 2004 to December 2005, forty-four female Landrace pigs, weighting between 32 and 38 Kg underwent orthotopic liver transplantation. The animals were divided into two groups, donor and recipient pairs, which received whole liver grafts. The surgical procedure was divided into four parts: harvested, back-table, hepatectomy of the recipient and implantation. We analyzed heart rate, blood gas, mean systemic arterial pressure (MAP-mmHg), central venous pressure, pH, Na-, K+, Cl-, Ca+ and urinary output. RESULTS: The mean anhepatic time was 69 min, cold ischemia was 252.2 min and back-table was 56.6 min. Blood pressure and heart rate dropped significantly during anhepatic phase and after revascularization. Blood gas and electrolytes alterations were observed during anhepatic and reperfusion phases. Although alterations were noted during these phases, the hemodynamic status was recovered and stabilized in the end of the surgery. CONCLUSIONS: Simplified technique of liver transplant was achieved and description of hemodynamic alterations was possible in pigs.
Orlando Jorge Martins Torres; Patrícia Brandão Pantoja; Erica Sampaio Barbosa; Cristiany de Almeida Barros; Elizabeth Teixeira Noguera Servin; Santiago Cirilo Noguera Servin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta cirúrgica brasileira / Sociedade Brasileira para Desenvolvimento Pesquisa em Cirurgia     Volume:  23     ISSN:  0102-8650     ISO Abbreviation:  Acta Cir Bras     Publication Date:    2008 Mar-Apr
Date Detail:
Created Date:  2008-03-31     Completed Date:  2009-05-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9103983     Medline TA:  Acta Cir Bras     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  135-9     Citation Subset:  IM    
Department of Surgery, Federal University of Maranhão, Brazil.
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MeSH Terms
Blood Gas Analysis
Blood Pressure / physiology
Electrolytes / blood
Heart Rate / physiology
Hemodynamics / physiology*
Hydrogen-Ion Concentration
Liver Transplantation / physiology*
Reg. No./Substance:

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