| Hemodynamic adaptation during pregnancy in chronic hypertension. | |
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MedLine Citation:
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PMID: 17710580 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To assess hemodynamic and NT-proANP changes in women with chronic hypertension during pregnancy. METHODS: Stroke volume index (SI), heart rate (HR), cardiac output index (CI), systemic vascular resistance index (SVRI), pulse wave velocity (PWV), and left cardiac work index (LCWI) were measured using whole-body impedance cardiography. Systolic blood pressure (SAP), mean arterial pressure (MAP), diastolic blood pressure (DAP), and pulse pressure (PP) were also measured. Arterial compliance was defined as the SI-to-PP ratio (SI/PP). Hemodynamic parameters and NT-proANP concentrations were assessed during the early and late second trimester, the third trimester, and after delivery in 20 women with essential hypertension and 30 normotensive women. RESULTS: Arterial blood pressure, SVRI, and PWV remained higher during the whole study period in chronic hypertensive compared with healthy pregnancies. In the early second trimester, women with chronic hypertension had significantly lower SI and NT-proANP concentrations than did normotensive women. CONCLUSION: The hemodynamics of chronic hypertension during pregnancy are characterized by persistent high vascular resistance. Lower SI and NT-proANP values found in chronic hypertensive pregnancies during the early second trimester may suggest a reduced intravascular volume increase during pregnancy. |
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Authors:
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Kati Tihtonen; Tiit Kööbi; Heini Huhtala; Jukka Uotila |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Hypertension in pregnancy : official journal of the International Society for the Study of Hypertension in Pregnancy Volume: 26 ISSN: 1064-1955 ISO Abbreviation: Hypertens Pregnancy Publication Date: 2007 |
Date Detail:
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Created Date: 2007-08-21 Completed Date: 2007-10-23 Revised Date: 2009-05-12 |
Medline Journal Info:
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Nlm Unique ID: 9421297 Medline TA: Hypertens Pregnancy Country: United States |
Other Details:
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Languages: eng Pagination: 315-28 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Tampere University Hospital, Tampere, Finland. kati.tihtonen@pshp.fi |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adaptation, Physiological* Adult Atrial Natriuretic Factor / metabolism* Blood Pressure / physiology Cardiac Output / physiology Case-Control Studies Female Heart Rate / physiology Humans Hypertension / metabolism, physiopathology* Pregnancy Pregnancy Complications, Cardiovascular / metabolism, physiopathology* Vascular Resistance / physiology |
| Chemical | |
Reg. No./Substance:
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85637-73-6/Atrial Natriuretic Factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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