| Hemodynamic abnormalities during coronary angiography: comparison of Hypaque-76, Hexabrix, and Omnipaque-350. | |
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MedLine Citation:
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PMID: 2920387 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The hemodynamic effects induced by coronary angiography in dogs with low osmolar ionic dimer Hexabrix (HB) and nonionic Omnipaque-350 (OM) were compared to the standard ionic contrast medium, Hypaque-76 (H76), both in the normal heart and in one with simulated severe cardiac disease. Left coronary angiography was performed in 12 "normal" closed-chest dogs with 10-cc injections of H76, HB, and OM in a randomized, blinded fashion. The maximal change in the left ventricular (LV) systolic pressure (SP), mean aortic pressure (MAP), left ventricular end diastolic pressure (LVEDP), and LV dp/dt were recorded. The LVSP and MAP fell 30 +/- 3 mm Hg and 26 +/- 4 mm Hg with H76, 22 +/- 2 mm Hg and 19 +/- 2 mm Hg with HB, and 7 +/- 1.5 mm Hg and 5 +/- 1 mm Hg with OM (P less than .001). The LVEDP increased 4.8 +/- 0.5 mm Hg with H76, 3 +/- 0.5 mm Hg with HB, but only 0.2 mm Hg with OM (P less than .001). The LV dp/dt decreased 392 +/- 63 mm Hg/sec with H76 and 235 +/- 21 mm Hg/sec with HB, but increased 411 +/- 50 mm Hg with OM (P less than .001). In eight additional open-chest dogs, left coronary angiography was performed 1 hr after occlusion of the proximal LAD coronary artery and in the presence of a critical circumflex coronary artery (CX) stenosis.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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Z E Piao; D K Murdock; M H Hwang; R M Raymond; P J Scanlon |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Catheterization and cardiovascular diagnosis Volume: 16 ISSN: 0098-6569 ISO Abbreviation: Cathet Cardiovasc Diagn Publication Date: 1989 Mar |
Date Detail:
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Created Date: 1989-04-11 Completed Date: 1989-04-11 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7508512 Medline TA: Cathet Cardiovasc Diagn Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 149-54 Citation Subset: IM |
Affiliation:
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Department of Medicine, Loyola University Medical Center, Maywood. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Angiography* Animals Contrast Media / toxicity* Coronary Angiography* Coronary Disease / radiography Diatrizoate / toxicity* Diatrizoate Meglumine / toxicity* Dogs Drug Combinations / toxicity Female Hemodynamics / drug effects* Iohexol / toxicity* Ioxaglic Acid / toxicity* Male Osmolar Concentration Random Allocation |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 0/Drug Combinations; 117-96-4/Diatrizoate; 131-49-7/Diatrizoate Meglumine; 59017-64-0/Ioxaglic Acid; 66108-95-0/Iohexol; 8064-12-8/urovision |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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