Document Detail

Hemodynamic Response to Sildenafil in Patients with Decompensated Congestive Heart Failure Can Be Predicted by Deceleration Time of Transmitral Flow.
MedLine Citation:
PMID:  25264753     Owner:  NLM     Status:  Publisher    
AIM: It remains unknown how sildenafil acutely provides hemodynamic alterations in patients with decompensated congestive heart failure. The aim of this study was to investigate whether myocardial and/or hemodynamic conditions affect hemodynamic response to sildenafil in patients with decompensated heart failure.
METHODS AND RESULTS: Twenty five consecutive patients with decompensated congestive heart failure were enrolled. The patients underwent echocardiography before and an hour after a single oral administration of sildenafil (20 mg). Sildenafil decreased pulmonary vascular resistance by 24% (p<0.05), and increased left ventricular (LV) time-velocity integral by 17% (p<0.05). Alteration of the ratio of peak velocity of early LV filling to early diastolic myocardial velocity (E/E'), an indicator of LV filling pressure, following administration of sildenafil, negatively associated with the deceleration time of early filling wave (DcT) at baseline. The patients with baseline DcT ≥ 200 msec. (n = 11) exhibited E/E' increase, whereas the patients with baseline DcT < 200 msec. (n = 14) exhibited E/E' decrease.
CONCLUSIONS: Administration of sildenafil elevated LV filling pressure in decompensated heart failure patients with shortened deceleration time of early diastolic transmitral flow.
Daisuke Morisawa; Shinichi Hirotani; Masataka Sugahara; Miho Fukui; Tomotaka Ando; Yoshiro Naito; Toshiaki Mano; Masaharu Ishihara; Tohru Masuyama
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-9-26
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  -     ISSN:  1533-4023     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:  2014 Sep 
Date Detail:
Created Date:  2014-9-29     Completed Date:  -     Revised Date:  2014-9-30    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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