| Hemodynamic, Hormonal and Renal Actions of Adrenomedullin-5 in Normal Conscious Sheep. | |
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MedLine Citation:
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PMID: 21436721 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Although blood pressure effects have been reported for adrenomedullin 5 (AM-5), a newly identified member of the CGRP super-family, little is known about other biological actions. We report the integrated hemodynamic, hormonal and renal actions of AM-5 (10 and 100 ng/kg/min each for 90 min) in normal conscious sheep. AM-5 reduced mean arterial pressure (MAP) by 12 mmHg at the end of high dose (p<0.001) in association with dose-dependant increments in heart rate (40 beats/min - high dose, p<0.001) and cardiac output (50% - high dose, p<0.001) and dose-dependent falls in calculated total peripheral resistance (CTPR, p<0.001). Plasma renin activity (PRA, four-fold increment, p<0.001)), aldosterone (two-fold increment, p=0.014) and cyclic AMP (50% increment, p<0.001) all rose in response to high dose AM-5. Urine volume and sodium excretion were unchanged. In conclusion, intravenous infusions of AM-5 administered to normal conscious sheep induced significant hemodynamic actions including reduced MAP and CTPR and increased heart rate and cardiac output. Concurrently, AM-5 activated plasma cyclic AMP, PRA and aldosterone. These actions are similar to those previously reported for AM and AM-2. Thus, AM-5 may be another important regulator of volume and pressure homeostasis and may play a role in the pathophysiology of heart disease. |
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Authors:
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Christopher J Charles; Miriam T Rademaker; A Mark Richards |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-3-23 |
Journal Detail:
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Title: Journal of cardiovascular pharmacology Volume: - ISSN: 1533-4023 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-3-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7902492 Medline TA: J Cardiovasc Pharmacol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Christchurch Cardioendocrine Research Group, University of Otago, Christchurch, New Zealand. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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