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Hemodynamic, Hormonal and Renal Actions of Adrenomedullin-5 in Normal Conscious Sheep.
MedLine Citation:
PMID:  21436721     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Although blood pressure effects have been reported for adrenomedullin 5 (AM-5), a newly identified member of the CGRP super-family, little is known about other biological actions. We report the integrated hemodynamic, hormonal and renal actions of AM-5 (10 and 100 ng/kg/min each for 90 min) in normal conscious sheep. AM-5 reduced mean arterial pressure (MAP) by 12 mmHg at the end of high dose (p<0.001) in association with dose-dependant increments in heart rate (40 beats/min - high dose, p<0.001) and cardiac output (50% - high dose, p<0.001) and dose-dependent falls in calculated total peripheral resistance (CTPR, p<0.001). Plasma renin activity (PRA, four-fold increment, p<0.001)), aldosterone (two-fold increment, p=0.014) and cyclic AMP (50% increment, p<0.001) all rose in response to high dose AM-5. Urine volume and sodium excretion were unchanged. In conclusion, intravenous infusions of AM-5 administered to normal conscious sheep induced significant hemodynamic actions including reduced MAP and CTPR and increased heart rate and cardiac output. Concurrently, AM-5 activated plasma cyclic AMP, PRA and aldosterone. These actions are similar to those previously reported for AM and AM-2. Thus, AM-5 may be another important regulator of volume and pressure homeostasis and may play a role in the pathophysiology of heart disease.
Authors:
Christopher J Charles; Miriam T Rademaker; A Mark Richards
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-3-23
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  -     ISSN:  1533-4023     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-3-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Christchurch Cardioendocrine Research Group, University of Otago, Christchurch, New Zealand.
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