Document Detail

Hemodynamic Effects of Left Atrial or Left Ventricular Cannulation for Acute Circulatory Support in a Bovine Model of Left Heart Injury.
MedLine Citation:
PMID:  25485565     Owner:  NLM     Status:  Publisher    
Our objective was to examine the hemodynamic effects of a trans-aortic axial flow catheter (Impella CP) in the left ventricle (LV) versus left atrial (LA) to femoral artery bypass using a centrifugal pump (TandemHeart: TH) in a bovine model of acute LV injury. In 3 male calves, we performed sequential activation of a CP then TH device in each animal. After 60 minutes of left anterior descending artery ligation, a CP was activated at maximal power. The CP was then removed and the TH activated at 5500 then a maximum of 7500 rotations per minute (RPM). The CP generated a maximum 3.1±0.2 liters/minute (LPM) of flow, while the TH at 5500 and 7500 RPM generated 3.1±0.4 and 4.4±0.3 LPM. At 3.1 LPM, the CP and TH reduced LV stroke work (LVSW) similarly. The TH reduced stroke volume while the CP did not. The CP reduced end-systolic pressure while the TH did not. At a maximum flow of 4.4 LPM, the TH provided a greater reduction in LVSW than maximal CP activation. This is the first report to compare the hemodynamic effects of trans-aortic LV unloading versus LA-to-FA bypass.
Navin K Kapur; Vikram Paruchuri; Duc Thinh; Lara Reyelt; Barbara Murphy; Corinna Beale; Courtney Bogins; Daniel Wiener; James Nilson; Michele Esposito; Scott Perkins; George Perides; Richard H Karas
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-12-5
Journal Detail:
Title:  ASAIO journal (American Society for Artificial Internal Organs : 1992)     Volume:  -     ISSN:  1538-943X     ISO Abbreviation:  ASAIO J.     Publication Date:  2014 Dec 
Date Detail:
Created Date:  2014-12-8     Completed Date:  -     Revised Date:  2014-12-9    
Medline Journal Info:
Nlm Unique ID:  9204109     Medline TA:  ASAIO J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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