Document Detail


Hemodynamic design requirements for in-series thoracic artificial lung attachment in a model of pulmonary hypertension.
MedLine Citation:
PMID:  22581034     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Recent thoracic artificial lung (TAL) prototypes have impedances lower than the natural lung. With these devices, proximal pulmonary artery (PA) to distal PA TAL attachment may be possible in patients without right ventricular dysfunction. This study examined the relationship between pulmonary system impedance and cardiac output (CO) to create TAL design constraints. A circuit with adjustable resistance and compliance (C) was attached in a PA-PA fashion with the pulmonary circulation of seven sheep with chronic pulmonary hypertension. The pulmonary system zeroth harmonic impedance modulus (Z(0)) was increased by 1, 2.5, and 4 mmHg/(L/min) above baseline. At each Z(0), C was set to 0, 0.34, and 2.1 ml/mmHg. The change in pulmonary system zeroth and first harmonic impedance moduli (ΔZ(0) and ΔZ(1)), the percent change in CO (%ΔCO), and the inlet and outlet anastomoses resistances were calculated for each situation. Results indicate that ΔZ(0) (p < 0.001) but not ΔZ(1) (p = 0.5) had a significant effect on %ΔCO and that %ΔCO = -7.45*ΔZ(0) (R(2) = 0.57). Inlet and outlet anastomoses resistances averaged 0.77 ± 0.16 and 0.10 ± 0.19 mmHg/(L/min), respectively, and the relationship between %ΔCO and TAL resistance, R(T), in mmHg/(L/min) was determined to be %ΔCO = -(7.45f)×(R(T) + 0.87), in which f = the fraction of CO through the TAL. Thus, newer TAL designs can limit %ΔCO to less than 10% if f < 0.75.
Authors:
Begum Akay; Julie A Foucher; Daniele Camboni; Kelly L Koch; Ayushi Kawatra; Keith E Cook
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  ASAIO journal (American Society for Artificial Internal Organs : 1992)     Volume:  58     ISSN:  1538-943X     ISO Abbreviation:  ASAIO J.     Publication Date:    2012 Jul-Aug
Date Detail:
Created Date:  2012-06-27     Completed Date:  2012-11-07     Revised Date:  2013-07-02    
Medline Journal Info:
Nlm Unique ID:  9204109     Medline TA:  ASAIO J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  426-31     Citation Subset:  IM    
Affiliation:
Department of Surgery, University of Michigan, Ann Arbor, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Artificial Organs
Disease Models, Animal
Equipment Design
Hemodynamics*
Humans
Hypertension, Pulmonary / therapy*
Lung / pathology*
Models, Statistical
Models, Theoretical
Pressure
Prosthesis Design
Pulmonary Artery / pathology
Pulmonary Circulation
Sheep
Thorax / pathology
Grant Support
ID/Acronym/Agency:
R01 HL089043/HL/NHLBI NIH HHS; R01 HL089043/HL/NHLBI NIH HHS
Comments/Corrections

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