| Hemodynamic design requirements for in-series thoracic artificial lung attachment in a model of pulmonary hypertension. | |
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MedLine Citation:
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PMID: 22581034 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Recent thoracic artificial lung (TAL) prototypes have impedances lower than the natural lung. With these devices, proximal pulmonary artery (PA) to distal PA TAL attachment may be possible in patients without right ventricular dysfunction. This study examined the relationship between pulmonary system impedance and cardiac output (CO) to create TAL design constraints. A circuit with adjustable resistance and compliance (C) was attached in a PA-PA fashion with the pulmonary circulation of seven sheep with chronic pulmonary hypertension. The pulmonary system zeroth harmonic impedance modulus (Z(0)) was increased by 1, 2.5, and 4 mmHg/(L/min) above baseline. At each Z(0), C was set to 0, 0.34, and 2.1 ml/mmHg. The change in pulmonary system zeroth and first harmonic impedance moduli (ΔZ(0) and ΔZ(1)), the percent change in CO (%ΔCO), and the inlet and outlet anastomoses resistances were calculated for each situation. Results indicate that ΔZ(0) (p < 0.001) but not ΔZ(1) (p = 0.5) had a significant effect on %ΔCO and that %ΔCO = -7.45*ΔZ(0) (R(2) = 0.57). Inlet and outlet anastomoses resistances averaged 0.77 ± 0.16 and 0.10 ± 0.19 mmHg/(L/min), respectively, and the relationship between %ΔCO and TAL resistance, R(T), in mmHg/(L/min) was determined to be %ΔCO = -(7.45f)×(R(T) + 0.87), in which f = the fraction of CO through the TAL. Thus, newer TAL designs can limit %ΔCO to less than 10% if f < 0.75. |
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Authors:
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Begum Akay; Julie A Foucher; Daniele Camboni; Kelly L Koch; Ayushi Kawatra; Keith E Cook |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: ASAIO journal (American Society for Artificial Internal Organs : 1992) Volume: 58 ISSN: 1538-943X ISO Abbreviation: ASAIO J. Publication Date: 2012 Jul-Aug |
Date Detail:
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Created Date: 2012-06-27 Completed Date: 2012-11-07 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 9204109 Medline TA: ASAIO J Country: United States |
Other Details:
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Languages: eng Pagination: 426-31 Citation Subset: IM |
Affiliation:
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Department of Surgery, University of Michigan, Ann Arbor, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Artificial Organs Disease Models, Animal Equipment Design Hemodynamics* Humans Hypertension, Pulmonary / therapy* Lung / pathology* Models, Statistical Models, Theoretical Pressure Prosthesis Design Pulmonary Artery / pathology Pulmonary Circulation Sheep Thorax / pathology |
| Grant Support | |
ID/Acronym/Agency:
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R01 HL089043/HL/NHLBI NIH HHS; R01 HL089043/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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